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Muscle specific kinase (MuSK) is a receptor tyrosine kinase that plays a crucial role in development and maintenance of the neuromuscular junction (NMJ). Lack of MuSK is lethal and defective MuSK signaling causes muscle weakness. MuSK activity is tightly regulated and requires the nerve-derived hepa...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-17 | PXD055117 | Pride
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
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