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TranscriptomicsTranscriptome analysis of immediate early events in mRNA-mediated cellular reprogramming of human foreskin fibroblasts
In this study human neonatal foreskin fibroblasts (HFF1 and BJ) were lipofected with an equal mixture of human reprogramming factor-encoding mRNAs. The cells were lysed and total RNA was harvested 24 hours post-transfection. Gene regulation was evaluated with respect to corresponding mock-transfecte...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-34943 | biostudies-arrayexpress
TranscriptomicsValproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach
Induced pluripotent stem cells (iPSCs) with potential for therapeutic applications can be derived from somatic cells via ectopic expression of a set of limited and defined transcription factors. However, due to risks of random integration of the reprogramming transgenes into the host genome, the low...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-26940 | biostudies-arrayexpress
TranscriptomicsStudy of expression changes during RPS4-mediated resistance in Arabidopsis using a temperature-inducible system
Innate immune responses of plant cells confer the first line of defence against pathogens. Signals generated by activated receptors are integrated inside the cell and converge on transcriptional programmes in the nucleus. The Arabidopsis Toll-related intracellular receptor RPS4 operates inside nucle...
ORGANISM(S): Arabidopsis thaliana 
2013-12-30 | E-GEOD-50019 | biostudies-arrayexpress
TranscriptomicsAssociation between in vivo bone formation and ex vivo migration capacity of human bone marrow stromal cells
Introduction: There is a clinical need for developing systemic transplantation protocols for use of human skeletal stem cells (also known bone marrow stromal stem cells) (hBMSC) in tissue regeneration. In systemic transplantation studies, only a limited number of hBMSC home to injured tissues sugges...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-69358 | biostudies-arrayexpress
TranscriptomicsErythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin
Epigenetic memory in induced pluripotent stem cells (iPSCs), with regards to their somatic cell type of origin, might lead to variations in their differentiation capacities. In this context, iPSCs from human CD34+ hematopoietic stem cells (HSCs) might be more suitable for hematopoietic differentiati...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-55109 | biostudies-arrayexpress
TranscriptomicsGenome-wide copy number analysis of patient-derived gliobastoma cell cultures
Genome-wide copy number variation profiles were analyzed in the patient-derived gliobastoma cell culture samples. For this purpose, gDNA was analyzed using the CytoScan® assay in combination with a one-color based labeling and hybridization protocol. Signals on the CytoScan® HD microarrays were dete...
ORGANISM(S): Homo sapiens 
2019-02-28 | E-MTAB-7649 | biostudies-arrayexpress
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