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GenomicsKinetic RNA polymerase II occupancy, associated histone marks, and mRNA accumulation reveal transcriptional and post-transcriptional mechanisms underlying circadian gene expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35790 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of epididymal adipose tissue from wild-type and Maf1 knockout mice
Purpose: To profile the effect of the Maf1 knockout on RNA polymerase II and RNA polymerase III transcriptomes in white adipose tissue Methods: Epididymal adipose tissue was harvested from overnight fasted 22-24 week old male mice that had been fed ad libitum on a chow diet. Total RNA was prepared f...
ORGANISM(S): Mus musculus 
2015-05-04 | E-GEOD-65976 | biostudies-arrayexpress
GenomicsGenome-wide localization of the RNA polymerase III transcription machinery in human cells
To characterize the pol III transcriptome in actively growing human cells, we used MR90hTeIrt lung fibroblasts, which are immortal but not transformed, with an intact Rb pathway. After formaldehyde cross-linking, chromatin was extracted and submitted to immunoprecipitation. To identify actively tr...
ORGANISM(S): Homo sapiens 
2010-02-11 | E-GEOD-18184 | biostudies-arrayexpress
GenomicsGenomic Study of RNA Polymerase II and III SNAPc-Bound Promoters Reveals a Gene Transcribed by both Enzymes and a Broad Use of Common Activators
SNAPc-dependent promoters are unique among cellular promoters in being very similar to each other, even though some of them recruit RNA polymerase II and other RNA polymerase III. We have examined all SNAPc-bound promoters present in the human genome. We find that there is a surprisingly small numbe...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-38303 | biostudies-arrayexpress
ProteomicsContrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
The conserved phosphoprotein MAF1 is the main known direct repressor of RNA polymerase III (Pol III). MAF1 is phosphorylated and inactivated by the nutrient-sensing TORC1 kinase, making MAF1 a nutrient effector for Pol III transcription. MAF1 has been associated with lipid metabolism in D. melanogas...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD040086 | Pride
Rna polymerase iii Transcription repressor Maf1 Hepatocyte Mouse Metabolic regulation 
TranscriptomicsTranscription profiling of mouse liver cells during the circadian cycle at 4 hour time resolution
Cyclic regulatory systems are ubiquitous in cells and tissues. In the liver rhythms in mRNA expression are determined by the homeostatic regulation that operates on daily circumstances. In particular the specific response to nutrients, as well as systemic and peripheral circadian oscillators, contri...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35789 | biostudies-arrayexpress
GenomicsGenome-wide MAF1-dependent regulation of RNA polymerase III transcription [DamIP-Seq]
In higher eukaryotes, an important mechanism to tune translation in different tissues and conditions is mTORC1-dependent regulation of tRNAs transcription by RNA polymerase III (Pol III), as the relative amount of tRNAs tightly coordinates with the translational needs of the cell. mTORC1 contributes...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-73928 | biostudies-arrayexpress
GenomicsGenome-wide MAF1-dependent regulation of RNA polymerase III transcription [ChIP-Seq]
In higher eukaryotes, an important mechanism to tune translation in different tissues and conditions is mTORC1-dependent regulation of tRNAs transcription by RNA polymerase III (Pol III), as the relative amount of tRNAs tightly coordinates with the translational needs of the cell. mTORC1 contributes...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-73926 | biostudies-arrayexpress
GenomicsGenome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle
To understand the transcriptional basis of circadian rhythms in mouse liver, we generated genome-wide profiles of RNA polymerase II (Pol 2) DNA occupancy and the histone modifications H3K4me3 and H3K36me3 around the circadian cycle. We found that Pol 2 occupancy at promoters and in gene bodies cycle...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35788 | biostudies-arrayexpress
TranscriptomicsGenome-wide MAF1-dependent regulation of RNA polymerase III transcription [RNA-Seq]
In higher eukaryotes, an important mechanism to tune translation in different tissues and conditions is mTORC1-dependent regulation of tRNAs transcription by RNA polymerase III (Pol III), as the relative amount of tRNAs tightly coordinates with the translational needs of the cell. mTORC1 contributes...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-73929 | biostudies-arrayexpress
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