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TranscriptomicsRNA-seq analysis of epididymal adipose tissue from wild-type and Maf1 knockout mice
Purpose: To profile the effect of the Maf1 knockout on RNA polymerase II and RNA polymerase III transcriptomes in white adipose tissue Methods: Epididymal adipose tissue was harvested from overnight fasted 22-24 week old male mice that had been fed ad libitum on a chow diet. Total RNA was prepared f...
ORGANISM(S): Mus musculus 
2015-05-04 | E-GEOD-65976 | biostudies-arrayexpress
ProteomicsTranscriptome and proteome changes triggered by overexpression of the transcriptional regulator Maf1 in the human pathogen Leishmania major
Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across eukaryotes. However, the knowledge about Maf1in protozoan parasites is scarce. To initiate the study of Maf1 in Leishmania major, we generated a cell line that...
ORGANISM(S): Leishmania major strain Friedlin 
2024-08-27 | PXD050692 | Pride
Leishmania major  pol iii transcription  maf1  trna  5s rrna 
GenomicsGenome-wide MAF1-dependent regulation of RNA polymerase III transcription [DamIP-Seq]
In higher eukaryotes, an important mechanism to tune translation in different tissues and conditions is mTORC1-dependent regulation of tRNAs transcription by RNA polymerase III (Pol III), as the relative amount of tRNAs tightly coordinates with the translational needs of the cell. mTORC1 contributes...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-73928 | biostudies-arrayexpress
TranscriptomicsEffects of Mediator subunit gene-deletions under conditions that repress ribosome synthesis
Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on Maf1, a protein that is essential for repressing tr...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-11397 | biostudies-arrayexpress
ProteomicsContrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
The conserved phosphoprotein MAF1 is the main known direct repressor of RNA polymerase III (Pol III). MAF1 is phosphorylated and inactivated by the nutrient-sensing TORC1 kinase, making MAF1 a nutrient effector for Pol III transcription. MAF1 has been associated with lipid metabolism in D. melanogas...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD040086 | Pride
Rna polymerase iii Transcription repressor Maf1 Hepatocyte Mouse Metabolic regulation 
TranscriptomicsMAF1 Represses CDKN1A through a Pol III-Dependent Mechanism
MAF1 represses Pol III-mediated transcription by interfering with TFIIIB and Pol III. Herein, we found that MAF1 knockdown induced CDKN1A transcription and chromatin looping concurrently with Pol III recruitment. Simultaneous knockdown of MAF1 with Pol III or BRF1 (subunit of TFIIIB) diminished the ...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-42239 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Aspergillus genes as a result of disrupting maf1
We identified a 14-3-3 homolog (maf1) in an EST library made under conditions conducive to aflatoxin biosynthesis. Disruption of this gene in A. flavus by site directed mutagenesis abolished aflatoxin production. The maf1 mutant was morphologically similar to wild type but had reduced conidiation an...
ORGANISM(S): Aspergillus flavus 
2010-05-27 | E-GEOD-861 | biostudies-arrayexpress
GenomicsGenome-wide MAF1-dependent regulation of RNA polymerase III transcription [ChIP-Seq]
In higher eukaryotes, an important mechanism to tune translation in different tissues and conditions is mTORC1-dependent regulation of tRNAs transcription by RNA polymerase III (Pol III), as the relative amount of tRNAs tightly coordinates with the translational needs of the cell. mTORC1 contributes...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-73926 | biostudies-arrayexpress
TranscriptomicsGenome-wide MAF1-dependent regulation of RNA polymerase III transcription [RNA-Seq]
In higher eukaryotes, an important mechanism to tune translation in different tissues and conditions is mTORC1-dependent regulation of tRNAs transcription by RNA polymerase III (Pol III), as the relative amount of tRNAs tightly coordinates with the translational needs of the cell. mTORC1 contributes...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-73929 | biostudies-arrayexpress
UnknownMaf1 phenotypes and cell physiology.
Not available
S-EPMC5882558 | biostudies-literature
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