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Unknown2839. Efficacy, Pharmacokinetics (PK), and Safety Profile of Suvratoxumab (MEDI4893), a Staphylococcus aureus Alpha Toxin (AT)-Neutralizing Human Monoclonal Antibody in Mechanically Ventilated Patients in Intensive Care Units; Results of the Phase 2 SAATELLITE Study Conducted by the Public-Private COMBACTE Consortium
Abstract

Background

Staphylococcus aureus (SA) pneumonia imposes significant morbidity and mortality in mechanically ventilated, intensive care unit (MV ICU) patients despite best clinical care. We assessed efficacy, PK, AT-neutralizing antibodies (AT NAbs), and safety of suvratoxumab (suvr...
S-EPMC6809370 | biostudies-literature
UnknownPerformance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies.

Background

Acute-on-chronic liver failure (ACLF) of various aetiologies is a complex syndrome with high short-term mortality and significant global burden.

Objective

To explore easily applicable diagnostic criteria and an accurate prognostic score for ACLF.

Design

Clinical data...
S-EPMC12703309 | biostudies-literature
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