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TranscriptomicsmiRNA expression profiling of primary melanoma tumors (cohort II)
We performed global microRNA expression profiling of a cohort of primary melanoma patient samples linked to a well-annotated clinical database. The goal of this study was to identify microRNA that are associated to or correlated with various clinical parameters and patient outcomes. Candidate microR...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-62371 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling of primary melanoma tumors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-62372 | biostudies-arrayexpress
TranscriptomicsProfiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas
Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the pre...
ORGANISM(S): Homo sapiens 
2010-07-24 | E-GEOD-23112 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling of primary melanoma tumors (cohort I)
We performed global microRNA expression profiling of a cohort of primary melanoma patient samples linked to a well-annotated clinical database. The goal of this study was to identify microRNA that are associated to or correlated with various clinical parameters and patient outcomes. Candidate microR...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-62370 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in lymphoma lines
MicroRNAs from lymphoma and leukemia cell lines with or without the 13q31 amplicon were quantitated using a custom microarray platform. 5ug total RNA from each line was labeled with cy3 and hybridized to a microarray that contains probes to 238 mouse and human mature microRNAs. Four data sets per ...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2399 | biostudies-arrayexpress
GenomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma [ChIP-seq]
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-68223 | biostudies-arrayexpress
GenomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma [native ChIP-seq]
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-68222 | biostudies-arrayexpress
TranscriptomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma [RNA-seq]
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-68221 | biostudies-arrayexpress
TranscriptomicsDual Pten/p53 suppression enhances Notch signaling and sarcoma progression
Soft tissue sarcomas (STS) are a heterogeneous group of tumors associated with poor clinical outcome. While a subset of STS are characterized by simple karyotypes and recurrent chromosomal translocations, the mechanisms driving cytogenetically complex sarcomas are largely unknown. Clinical evidence ...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42103 | biostudies-arrayexpress
TranscriptomicsMiR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis
To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets simultaneously. We performed a microRNA analysis of h...
ORGANISM(S): Homo sapiens 
2011-03-08 | E-GEOD-27718 | biostudies-arrayexpress
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