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MetabolomicsIntegration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance
The development of reliable, mixed-culture biotechnological processes hinges on understanding how microbial ecosystems respond to disturbances. Here we reveal extensive phenotypic plasticity and niche complementarity in oleaginous microbial populations from a biological wastewater treatment plant. W...
2021-04-06 | MTBLS2021 | MetaboLights
TranscriptomicsWnt secretion protein Evi/Gpr177 promotes glioma tumorigenesis
Silencing of Evi and beta-catenin in U87MG cells
ORGANISM(S): Homo sapiens 
2012-06-29 | E-MTAB-776 | biostudies-arrayexpress
ProteomicsThe phosphoproteome of choroid plexus epithelial cells following infection with Neisseria meningitidis
The Gram-negative bacterium Neisseria meningitidis causes meningitis in humans and has been demonstrated to manipulate or alter host signalling pathways during infection of the central nervous system. In this study, the phosphoproteome of an in vitro model of the blood-cerebrospinal fluid barrier wa...
ORGANISM(S): Homo sapiens (Human) 
2023-03-31 | PXD038560 | Pride
Tmt Human Exploris 480 Neisseria meningitidis Lcms 
ProteomicsCalcitriol promotes differentiation of glioma stem-like cells and increases their susceptibility to temozolomide
Cancer cells with a stem-like phenotype are commonly described in glioblastoma, the most common primary adult brain cancer, that are thought to be highly tumorigenic. This phenotype comprimes high self renewal capacity and resistance against chemotherapy and radiation therapy, thereby promoting tumo...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD026789 | Pride
Calcitriol  vitamin d3  glioblastoma  glioblastoma stem-like cells 
UnknownDual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages.
Not available
S-EPMC9647079 | biostudies-literature
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
ProteomicsHistone Modification Analysis of Oligodendroglioma and Astrocytoma Brain Cancer Samples
WHO classification for tumors of the central nervous system strongly endorses molecular tests for the precise diagnosis of diffuse gliomas. While alterations in the DNA methylation status of gliomas are already well documented and used in specialised clinical centers to distinguish between brain tum...
ORGANISM(S): Homo sapiens (Human) 
2020-01-17 | PXD015151 | Pride
Oligodendroglioma Histone modifications Brain cancer Astrocytoma Histone epi-proteome 
TranscriptomicsAn eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. Howev...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-22762 | biostudies-arrayexpress
UnknownIn vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.
Not available
S-EPMC8476619 | biostudies-literature
TranscriptomicsGenome-wide copy number analysis of patient-derived gliobastoma cell cultures
Genome-wide copy number variation profiles were analyzed in the patient-derived gliobastoma cell culture samples. For this purpose, gDNA was analyzed using the CytoScan® assay in combination with a one-color based labeling and hybridization protocol. Signals on the CytoScan® HD microarrays were dete...
ORGANISM(S): Homo sapiens 
2019-02-28 | E-MTAB-7649 | biostudies-arrayexpress
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