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Transcriptomicscalcitriol triggers axogenesis and myelination
Using pangenomic cDNA microarrays and qPCR techniques, we identified the genes regulated by calcitriol (1,25 (OH)D3, 10 nM) in dorsal root ganglia and/or Schwann cells. After 24 hours of calcitriol supplementation, we found a modified expression of many genes involved in axogenesis and myelination.
ORGANISM(S): Rattus norvegicus 
2012-04-07 | E-MEXP-3491 | biostudies-arrayexpress
ProteomicsCalcitriol-Driven IL-10 IL-22 ILC Differentiation from ILCPs
Calcitriol, the active metabolite of vitamin D, modulates immune responses via vitamin D receptor (VDR)-dependent signaling, but its role in innate lymphoid cell (ILC) development remains underexplored. This study elucidates the mechanisms by which calcitriol promotes the differentiation and migrati...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-14 | PXD068530 | Pride
Ilc Calcitriol Ilcp Differentiation 
GenomicsGenome-wide Analysis of Vitamin D Receptor Binding By ChIP-Seq
We used ChIP-Seq to identify the genomic locations bound by the vitamin D receptor (VDR) in two lymphoblastoid cell lines (LCLs) (CEPH individuals GM10855 and GM10861 from the International HapMap Project) before and after calcitriol treatment for 36 hours. Immunoprecipitated DNA was sequenced using...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-22484 | biostudies-arrayexpress
ProteomicsCalcitriol promotes differentiation of glioma stem-like cells and increases their susceptibility to temozolomide
Cancer cells with a stem-like phenotype are commonly described in glioblastoma, the most common primary adult brain cancer, that are thought to be highly tumorigenic. This phenotype comprimes high self renewal capacity and resistance against chemotherapy and radiation therapy, thereby promoting tumo...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD026789 | Pride
Calcitriol  vitamin d3  glioblastoma  glioblastoma stem-like cells 
GenomicsCalcipotriol vs. calcitriol in hepatocellular gene expression
Calcipotriol vs. calcitriol in hepatocellular gene expression
PRJNA415972 | ENA
TranscriptomicsCalcitriol deregulates AR signaling to inhibit prostate cancer progression in the TRAMP model
The mechanism of action of vitamin D in prostate cancer (PCa) remains poorly defined, with most mechanisms identified being highly cell type and model specific. One of the underlying factors for these diverse mechanisms may be the use of overly simplistic in vitro model systems to study the complex ...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-57382 | biostudies-arrayexpress
TranscriptomicsCalcitriol supplementation effects on Ki67 expression and transcriptional profile of breast cancer specimens from post-menopausal patients
Background: Breast cancer patients present lower 1,25(OH)2D3 or 25(OH)D3 serum levels than unaffected women. Although 1,25(OH)2D3 pharmacological concentrations of 1,25(OH)2D3 may exert antiproliferative effects in breast cancer cell lines, much uncertainty remains about the effects of calcitriol su...
ORGANISM(S): Homo sapiens 
2012-02-18 | E-GEOD-35925 | biostudies-arrayexpress
ProteomicsComparative Proteomics of Calcitriol-treated high- and no-responding Glioma stem-like cells
Glioblastoma is the most common primary brain cancer and is associated with poor survival and high rates of recurrent diseases. The median survival using standard radio-chemotherapy is 15 months and the 5-year survival rate is below 5%. It is hypothesized that treatment resistance, diffuse infiltrat...
ORGANISM(S): Homo sapiens (Human) 
2023-11-04 | PXD041634 | Pride
Glioma stem-like cells Calcitriol Glioblastoma Vitamin d3 Glioma 
GenomicsCalcitriol induces a distinctive transcriptional program in Chronic Lymphocytic Leukemia (CLL) cells
Calcitriol induces a distinctive transcriptional program in Chronic Lymphocytic Leukemia (CLL) cells
PRJNA681850 | ENA
GenomicsAntagonistic interaction between androgen signaling and vitamin D signaling in prostate cancer [ChIP-Seq]
Vitamin D induces anti-proliferative and differentiating effects in prostate cancer. Thus calcitriol, the hormonally active form of Vitamin D, and its analogs have been extensively studied in prostate cancer cells. Yet despite its importance, relatively little is known about the genome-scale mechani...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-64656 | biostudies-arrayexpress
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