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TranscriptomicsRNA-seq of mouse common lymphoid progenitors, innate lymphoid cell progenitors and NK cell progenitors
Natural Killer (NK) cells at different developmental stages (common lymphoid progenitor (CLP), innate lymphoid cell progenitors (ILCP), and refined NK progenitor (NKP)) were collected from Vav1+iCre FOXO1,3flox/flox mice (C57BL/6 background). Total RNA was harvested and sequenced with a strand-speci...
ORGANISM(S): Mus musculus 
2022-02-06 | E-MTAB-9560 | biostudies-arrayexpress
UnknownIL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs.
Not available
S-EPMC9304618 | biostudies-literature
GenomicsSystemic human ILC precursors provide a substrate for tissue ILC differentiation
Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCP). Still, how ILCP relate to mature tissue-resident ILCs remains unclear. We identify ILCP that are present in the blood and all tested lymphoid and non-lymp...
ORGANISM(S): Homo sapiens 
2017-03-19 | GSE90640 | GEO
TranscriptomicsIntestinal ILC progenitors differentially generate ILC subsets dependent on the recipient tissue microenvironment
Innate lymphoid cells (ILC) are critical in maintaining tissue homeostasis, and during infection and inflammation. Using combinatorial reporter mice we demonstrate the existence of rare, small intestinal lamina propria (siLP)- resident, ILC progenitors (siLP-ILCP) in adult mice. Transfer of siLP-ILC...
ORGANISM(S): Mus musculus 
2024-08-01 | GSE234835 | GEO
UnknownCirculating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients.
Not available
S-EPMC8360187 | biostudies-literature
TranscriptomicsDevelopment and differentiation of early innate lymphoid progenitors
Early innate lymphoid progenitors (EILP) have recently been identified in the mouse adult bone marrow as a multipotential progenitor population committed to ILC lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor-successor ...
ORGANISM(S): Mus musculus 
2017-11-15 | GSE81530 | GEO
UnknownRecipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors.
Not available
S-EPMC11379955 | biostudies-literature
GenomicsDynamic chromatin structure during early ILC progenitor differentiation
To characterize the epigenomes during early ILC progenitor differentiation, we did DNase-seq, CUT&RUN and scMNase-seq assays in all-lymphoid progenitor (ALP), early innate lymphoid progenitor (EILP), and innate lymphoid cell progenitor (ILCP) cells.
ORGANISM(S): Mus musculus 
2019-05-30 | GSE128483 | GEO
UnknownNotch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation.
Not available
S-EPMC9329340 | biostudies-literature
TranscriptomicsSystemic human ILC precursors provide a substrate for tissue ILC differentiation
Innate lymphoid cells (ILC) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCP). Still, how ILCP relate to mature tissue-resident ILCs remains unclear. We observed that a population of CD117+ ILC from peripheral blood (PB) of healthy do...
ORGANISM(S): Homo sapiens 
2017-03-19 | GSE90834 | GEO
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