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MetabolomicsCD5L inhibits allergic airway inflammation by lysophosphatidylcholine-induced ILC2 apoptosis

Group 2 innate lymphoid cells (ILC2s) play key roles in allergic asthma development. We have previously revealed the inhibitory effect of CD5 antigen-like protein (CD5L) on allergic airway inflammation. Here, we analyzed the effect of CD5L on ILC2s.

2025-09-04 | MTBLS12937 | MetaboLights
MetabolomicsBlocking NKp46-CCR6-ILC3 autophagy alleviates necrotizing enterocolitis by restoring energy metabolism balance

Group 3 innate lymphoid cells (ILC3s) play a crucial role in intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) in neonates; however, the mechanisms by which ILC3s contribute to NEC remain unclear. In this study, single-cell transcriptomics, in vivo experiments on T cell-de...

2026-04-12 | MTBLS12891 | MetaboLights
TranscriptomicsInnate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor
Subtypes of innate lymphoid cells (ILC), defined by effector function and transcription factor expression, have recently been identified. In the adult, ILC derive from common lymphoid progenitors in bone marrow, although transcriptional regulation of the developmental pathways involved remains po...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-65850 | biostudies-arrayexpress
MetabolomicsGermacrone Protects Against DSS Induced Colitis Through a Gut Microbiota Derived Indole-3-Carboxylic Acid-AhR-ILC3/IL-22 Axis
Ulcerative colitis (UC) is a chronic recurrent inflammatory bowel disease, which is characterized by intestinal microbiota dysbiosis, intestinal barrier and mucosal immune dysfunction. Given the limited effect of biological agents for UC, there is an urgent need to develop more effective pharmacolog...
2026-08-30 | MTBLS15475 | MetaboLights
ProteomicsCalcitriol-Driven IL-10 IL-22 ILC Differentiation from ILCPs
Calcitriol, the active metabolite of vitamin D, modulates immune responses via vitamin D receptor (VDR)-dependent signaling, but its role in innate lymphoid cell (ILC) development remains underexplored. This study elucidates the mechanisms by which calcitriol promotes the differentiation and migrati...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-14 | PXD068530 | Pride
Ilc Calcitriol Ilcp Differentiation 
TranscriptomicsGene expression profile at single cell level of vessel associated kidney NKp46+ ILC from healthy and nephritic NZB/W lupus prone mice
Kidney vessel associated NKp46+ ILC have never been characterized at single cell level before. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of kidney vessel associated NKp46+ ILC in the kidney
ORGANISM(S): Mus musculus 
2026-03-04 | E-MTAB-16156 | biostudies-arrayexpress
GenomicsIntestinal ILC progenitors differentially generate ILC subsets dependent on the recipient tissue microenvironment
Intestinal ILC progenitors differentially generate ILC subsets dependent on the recipient tissue microenvironment
PRJNA983318 | ENA
TranscriptomicsMicroarray based gene expression for invasive lobular cancer samples (RATHER)
As part of the RATHER (RAtional THERapy for breast cancer: individualized treatment for difficult-to-treat breast cancer subtypes) consortium, expression profiling of 144 untreated primary invasive lobular carcinoma (ILC) breast cancer tissues and 15 ILC cell lines was performed using microarray. Ge...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-68057 | biostudies-arrayexpress
TranscriptomicsThe basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs the development of a committed bone marrow pr...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62337 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of murine Bcl6-deficient ILC against wild-type controls
Innate lymphoid cells (ILC) are tissue-resident effector cells with important roles in tissue homeostasis, protective immunity and inflammatory disease. Here we investigated the role of the transcription factor Bcl6 in small intestinal innate lymphoid cells. Specifically, we performed single-cell RN...
ORGANISM(S): Mus musculus 
2023-10-31 | E-MTAB-12864 | biostudies-arrayexpress
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