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UnknownThe Synthesis and Absolute Configuration of Enantiomeric Pure (R)- and (S)-3-(piperidin-3-yl)-1H-Indole Derivatives
Not available
S-EPMC9820373 | biostudies-literature
UnknownNeospora caninum Infection Triggers S-phase Arrest and Alters Nuclear Characteristics in Primary Bovine Endothelial Host Cells.
Not available
S-EPMC9469085 | biostudies-literature
TranscriptomicsLOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients
MGMT promoter methylation status is currently the only established molecular prognosticator in IDH wild-type glioblastoma multiforme (GBM). Therefore, we aimed to discover novel therapy-associated epigenetic biomarkers. After enrichment for hypermethylated fractions using methyl-CpG-immunoprecipitat...
ORGANISM(S): Homo sapiens 
2016-03-10 | E-GEOD-74561 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of export factors in Drosphila Schneider cell lines
Six different endogenous Drosophila proteins (all potential export factors) have been inactivated using RNAi and leptomycin B (LMB) treatments. Five different endogenous Drosophila proteins (all potential export factors) have been targeted by RNAi. The effect on mRNA export is analyzed by monitoring...
ORGANISM(S): Drosophila melanogaster 
2003-05-15 | E-MEXP-4 | biostudies-arrayexpress
ProteomicsCaspase-8’s non-apoptotic role is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.
Excessive inflammation and cytokine release are hallmarks of severe COVID-19. Programmed cell death is known to drive inflammation, however, its relevance in the pathogenesis of severe COVID-19 is unclear. Using a combination of gene-targeted murine models and transcriptomic approaches we found that...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-20 | PXD057656 | Pride
Sars-cov-2  caspase-8  inflammation  flip  covid-19  cytokines 
TranscriptomicsGene expression data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-49243 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the migrating human CD4+ T cell population from the spleen of humanized mice in response to treatment with Teplizumab or hIg
In order to identify genes expressed by cells that leave the spleen, the spleens were harvested from untreated reconstituted humanized mice (N=4) and a single cell suspension was prepared . The cultures were treated with either teplizumab (anti human CD3 hOKT3g1(Ala-Ala)) or hIg for 18 hrs in vitro...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-34163 | biostudies-arrayexpress
UnknownDeletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis.
Not available
S-EPMC10244435 | biostudies-literature
TranscriptomicsRNA-seq of Leptospirillum ferriphilum DSM 14647 cells treated with quorum sensing signal compounds
Differential gene expression analysis of Leptospirillum ferriphilum DSM 14647 cells treated with quorum sensing singnal compounds. Briefly, Leptospirillum ferriphilum DSM 14647 cells were grown to early stationary phase in Mackintosh basal salt solution (Mac medium) pH 1.8 (Mackintosh 1978) with 71....
ORGANISM(S): Leptospirillum ferriphilum DSM 14647 
2021-03-01 | E-MTAB-9845 | biostudies-arrayexpress
UnknownTranslational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.
Not available
S-EPMC5070554 | biostudies-literature
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