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MetabolomicsInfection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread...
2018-10-22 | MTBLS652 | MetaboLights
GenomicsOncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
ChIP-sequencing reads from Oncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication, accepted to PLOS Pathogens
ORGANISM(S): Homo sapiens 
2016-06-01 | E-MTAB-4356 | biostudies-arrayexpress
TranscriptomicsSmall RNA deep-sequencing identifies microRNAs and other small non-coding RNAs from human herpesvirus 6 (HHV-6B)
Roseolovirus, or human herpesvirus 6 (HHV-6) is a ubiquitous human pathogen infecting over 95% of the population by the age of two years. As with other herpesviruses, reactivation of HHV-6 can present with severe complications in immunocompromised individuals. Recent studies have highlighted the imp...
ORGANISM(S): Human herpesvirus 6B 
2012-01-01 | E-GEOD-34196 | biostudies-arrayexpress
TranscriptomicsHelminth Infection Reactivates Latent γ-herpesvirus Via Cytokine Competition at a Viral Promoter
Mammals are co-infected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the cytokine interleukin-4 (IL-4) and the activation of the transcription factor Stat6, reactivated murine gammaherpesvirus infection in vivo. I...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-58116 | biostudies-arrayexpress
TranscriptomicsEpstein–Barr virus (EBV) Rta-mediated cell cycle arrest enables permissive replication of EBV and Kaposi’s sarcoma-associated herpesvirus in 293 cells
Epstein-Barr virus (EBV) Rta is a latent-lytic molecular switch evolutionarily conserved in all gamma-herpesviruses. In previous studies, doxycycline-inducible Rta was shown to potently produce an irreversible G1 arrest followed by cellular senescence in 293 cells. Here, we demonstrate that in this ...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-24587 | biostudies-arrayexpress
GenomicsOncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
Oncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
PRJEB12546 | ENA
TranscriptomicsmicroRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP [Illumina]
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and, often, EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in viral latency and lymphomagenesis. Here we ...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-32109 | biostudies-arrayexpress
GenomicsAnguillid herpesvirus 1
Anguillid herpesvirus 1 Raw sequence reads
PRJNA1456909 | ENA
ProteomicsThe Kaposi’s sarcoma-associated herpesvirus ORF11 protein interacts with pre-ribosome complexes during lytic replication
Historically, ribosomes have been viewed as unchanged homogeneous macromolecular machines with no intrinsic regulatory capacity for mRNA translation. However, an emerging concept is that heterogeneity of ribosomal composition exists, which can exert a regulatory function or specificity in translatio...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-12-21 | PXD032367 | Pride
Microbiology/kaposi’s sarcoma-associated herpesvirus/specalised ribosomes/ribosome biogenesis 
TranscriptomicsHITS-CLIP analysis uncovers a link between the Kaposi's sarcoma associated herpesvirus ORF57 protein and host pre-mRNA metabolism
The Kaposi's sarcoma associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi's sarcoma, primary effusion lymphoma (PEL), and some forms of multicentric Castleman's disease. The KSHV ORF57 protein is a conserved posttranscriptional regulator of gene expression that is essential for vir...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-64413 | biostudies-arrayexpress
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