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ProteomicsThe yeast AIF homolog Nde1 integrates metabolic and proteostatic signals on the mitochondrial surface and executes cell death
Little is known about the proteolytic turnover of mitochondrial proteins under static growth conditions. Combining dynamic isotope labeling and mass spectrometry in yeast cells, we found an exceptionally high turnover for the NADH dehydrogenase Nde1. This homolog of the mammalian apoptosis inducing ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-06 | PXD012531 | Pride
Mitochondria Protein turnover Nde1 Yeast Apoptosis 
ProteomicsMitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins
Cellular functionality relies on a well-balanced, but highly dynamic proteome. Dysfunctionof mitochondrial protein import leads to the cytosolic accumulation of mitochondrial precursor proteins which compromise cellular proteostasis and trigger the mitoprotein-induced stress response. To dissect the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-21 | PXD037741 | Pride
Mitochondria / proteasome / protein folding / proteostasis / thermal proteome profiling / stress response 
ProteomicsMitoprotein-induced stress launches a global transcriptional fail-safe program
Most mitochondrial proteins are synthesized as cytosolic precursor proteins before being imported into mitochondria. Cytosolic accumulation of mitochondrial precursors hazards cellular fitness and is associated with a growing number of diseases, but is not observed under physiological conditions. In...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-01-14 | PXD011789 | Pride
Mitochondria Chaperones Protein import Yeast Proteasome Oxidative phosphorylation Stress response 
ProteomicsIncreased levels of the mitochondrial import factor Mia40 can prevent the aggregation of polyQ proteins in the cytosol
The formation of protein aggregates is a hallmark of neurodegenerative diseases. Observations on patient material and model systems demonstrated links between aggregate formation and declining mitochondrial functionality, but the causalities remained unclear. We used yeast as model system to analyze...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-05 | PXD023902 | Pride
Huntingtin / mia40 / mitochondria / protein aggregation / protein translocation 
GenomicsTelomerase activation by genomic rearrangements in high-risk neuroblastoma
Neuroblastoma is a malignant pediatric tumor of the sympathetic nervous system1. Roughly half of these tumors regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavorable clinical course despite intensive multimodal treatment, and their molecular b...
EGAS00001001308 | EGA
UnknownGenome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy.
Not available
S-EPMC4357422 | biostudies-literature
Genomicsena-DATASET-UCL-ICH-25-11-2015-12:32:35:398-26 - samples
Description not provided
EGAD00001001687 | EGA
GenomicsDAC University Hospital Cologne
Data Access Committee EGAC00001000361
EGAC00001000361 | EGA
UnknownExtensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data.
Not available
S-EPMC10327023 | biostudies-literature
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Not available
S-EPMC7350392 | biostudies-literature
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