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ProteomicsA priority code in mitochondrial presequences - Data set 1: IPs from rabbit reticulocyte lysates
The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as matrix targeting signals. Presequences consistently form amphipathic helices, but they considerably dif...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-09 | PXD053210 | Pride
Yeast mitochondrial import 
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 4: AP-MS for Apj1, Pwp2 and Utp18
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD062600 | Pride
Mitochondria Yeast 
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 1: proximity labelling
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD057245 | Pride
Mitochondria Yeast 
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 5: MRP17 - AP-MS
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD054381 | Pride
Yeast mitochondrial import 
ProteomicsA priority code in mitochondrial presequences - Data set 2: Proteome of WT and CNS1 mutant yeast strains
The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as mitochondrial targeting signals. Presequences consistently form amphipathic helices, but they considera...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-09 | PXD059975 | Pride
Mitochondria Yeast 
ProteomicsMitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol - Data Set 1: Global Proteome TMT
Hundreds of mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational reaction. The early stages in mitochondrial protein targeting are poorly understood. Here we show that in baker’s yeast, the cytosol has the capacity to transiently stor...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-17 | PXD035760 | Pride
Mitochondrial import Ubiquitin proteasome system Rpn4 Mitostore 
ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex - DATA SET II
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD036508 | Pride
Mitochondrial import Ubc8 Yeast metabolism 
ProteomicsMitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol - Data Set 2: Hsp104 AP-MS
Hundreds of mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational reaction. The early stages in mitochondrial protein targeting are poorly understood. Here we show that in baker’s yeast, the cytosol has the capacity to transiently stor...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD035762 | Pride
Mitostores Mitochondrial import Hsp104 
ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex - Data Set 2
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD033193 | Pride
Mitochondrial import Metabolic switch 
ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD033171 | Pride
Mitochondrial import Metabolic switch 
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