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TranscriptomicsDicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness [RNA_correlations]
Epigenetic mechanisms can be influenced by environmental cues and thus evoke phenotypic variation. This plasticity can be advantageous for adaption, but also detrimental if not under tight control. Although having attracted considerable interest, it remains largely unknown if and how environmental c...
ORGANISM(S): Schizosaccharomyces pombe 
2015-04-23 | E-GEOD-60638 | biostudies-arrayexpress
TranscriptomicsDicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness [RNA_profiles]
Epigenetic mechanisms can be influenced by environmental cues and thus evoke phenotypic variation. This plasticity can be advantageous for adaption, but also detrimental if not under tight control. Although having attracted considerable interest, it remains largely unknown if and how environmental c...
ORGANISM(S): Schizosaccharomyces pombe 
2015-04-23 | E-GEOD-60429 | biostudies-arrayexpress
ProteomicsNuclear Hsp104 safeguards the dormant translation machinery during quiescence
The resilience of cellular proteostasis declines with age, which drives protein aggregation and compromises viability. The nucleus has emerged as a key quality control compartment that unloads the cytosolic protein biosynthesis system from misfolded proteins. Here, we find that age-associated metabo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-12 | PXD042987 | Pride
Quiescence Eif2 Aging Nuclear protein quality control Protein aggregation Disaggregation Translation Proteasome Hsp104 Ribosome reactivation Bioid 
ProteomicsMitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol - Data Set 2: Hsp104 AP-MS
Hundreds of mitochondrial precursor proteins are synthesized in the cytosol and imported into mitochondria in a post-translational reaction. The early stages in mitochondrial protein targeting are poorly understood. Here we show that in baker’s yeast, the cytosol has the capacity to transiently stor...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD035762 | Pride
Mitostores Mitochondrial import Hsp104 
GenomicsDicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness [RNA_correlations]
Epigenetic mechanisms can be influenced by environmental cues and thus evoke phenotypic variation. This plasticity can be advantageous for adaption, but also detrimental if not under tight control. Although having attracted considerable interest, it remains largely unknown if and how environmental c...
ORGANISM(S): Schizosaccharomyces pombe 
2015-04-23 | GSE60638 | GEO
GenomicsDicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness [RNA_profiles]
Epigenetic mechanisms can be influenced by environmental cues and thus evoke phenotypic variation. This plasticity can be advantageous for adaption, but also detrimental if not under tight control. Although having attracted considerable interest, it remains largely unknown if and how environmental c...
ORGANISM(S): Schizosaccharomyces pombe 
2015-04-23 | GSE60429 | GEO
UnknownDesign principles to tailor Hsp104 therapeutics.
Not available
S-EPMC11815640 | biostudies-literature
UnknownDesign principles to tailor Hsp104 therapeutics.
Not available
S-EPMC11071516 | biostudies-literature
UnknownTuning Hsp104 specificity to selectively detoxify α-synuclein.
Not available
S-EPMC10530207 | biostudies-literature
UnknownSubstrate Discrimination by ClpB and Hsp104.
Not available
S-EPMC5447042 | biostudies-literature
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