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TranscriptomicsA role for Dicer in immune regulation
A study of the miRNA profile CD4 T cells compared to T reg cells; of activated and naive T cells; and the miRNA profile conferred by enforced expression of Foxp3. Keywords: cell type comparison Fifteen arrays broken down into three broader experiments as referenced by series GSE6003 - a comparison o...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6056 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA profile of natural T reg cells with conventional CD4+CD25- T cells
Low molecular weight RNA from conventional T cells and T reg cells was hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell type comparison Six arrays representing three biological replicates and dyeswaps of each.
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6003 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA profile of Foxp3-transduced activated T cells with control vector-transduced activated T cells
Activated T cells were transduced with either Foxp3-IRES-GFP or IRES-GFP control vector. Low molecular weight RNA from cells was extracted 72h or 96h later and hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell type comparison Four arra...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6007 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA profile of activated T cells to naive T cells
T cells were activated for 1, 3 or 10 days using plate-bound anti-TCR and anti-CD28. Low molecular weight RNA from conventional T cells and activated T cells was hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell state analysis Five arr...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-6006 | biostudies-arrayexpress
GenomicsGenome-wide identification of functional elements regulated by T-bet and GATA3 in human T-cells
T-bet and GATA3 induce differentiation of CD4+ T-cells into Th1 or Th2 effectors. These exhibit a range of different properties but understanding of T-bet and GATA3 function is mostly limited to the murine Ifng and Il4/Il5/Il13 loci. We hypothesised that extending such analyses across the human geno...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-31320 | biostudies-arrayexpress
TranscriptomicsT-bet and GATA-3 act in combination through distal regulatory elements across the genome
Gene expression measurements in Thp, Th1 and Th2 cells polarised from naIve CD4+ T-cells isolated from wildtype and T-bet fl/fl x Cd4-Cre BALB/c mice or from WT and Gata-3 fl/fl x Tnfrsf4-Cre C57BL/6 mice.
ORGANISM(S): Mus musculus 
2012-10-29 | E-TABM-1187 | biostudies-arrayexpress
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