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TranscriptomicsLactobacillus acidophilus and Helicobacter pylori stimulation of bone marrow derived macrophage
Helicobacter pylori causes chronic gastritis and avoids elimination by the immune system of the infected host. The commensal bacterium Lactobacillus acidophilus has been reported to exert beneficial effects as a supplement during H. pylori eradication therapy. In the present study, we applied whole ...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-42622 | biostudies-arrayexpress
UnknownAssembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae.
Not available
S-EPMC10085707 | biostudies-literature
TranscriptomicsLineage relationship in human dendritic cells
The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compa...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32400 | biostudies-arrayexpress
TranscriptomicsLineage relationship in human dendritic cells - cDNA arrays
The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compa...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32648 | biostudies-arrayexpress
TranscriptomicsSilencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape mechanisms
Breast cancer metastasis to bone is a critical determinant of long-term survival after treatment of primary tumors. We used a mouse model of spontaneous bone metastasis to determine new molecular mechanisms. Differential transcriptome comparisons of primary and metastatic tumor cells revealed that a...
ORGANISM(S): Mus musculus 
2012-07-17 | E-GEOD-37828 | biostudies-arrayexpress
TranscriptomicsStructural basis of a novel Interferon b signaling axis mediated via the ifnar1 receptor
Type I interferons (IFNs) are a family of cytokines that play an important role in regulating immune responses to pathogens and tumors and are used therapeutically. All IFNs are considered to signal via the heterodimeric IFNAR1-IFNAR2 complex, yet some subtypes such as IFN? can exhibit distinct fun...
ORGANISM(S): Mus musculus 
2013-07-13 | E-GEOD-48827 | biostudies-arrayexpress
TranscriptomicsComparison of matched primary and metastasis 4T1.2 syngeneic mammary tumor model of spontaneous bone metastasis
Breast cancer metastasis to bone is a critical determinant of long-term survival after treatment of primary tumors. We used a mouse model of spontaneous bone metastasis to determine new molecular mechanisms. Differential transcriptome comparisons of primary and metastatic tumor cells revealed that a...
ORGANISM(S): Mus musculus 
2012-07-17 | E-GEOD-37975 | biostudies-arrayexpress
TranscriptomicsLPS hypersensitivity of gp130 mutant mice is independent of elevated hematopoietic TLR4 signaling
The inflammatory mediator IL6 induced by LPS, which signals via TLR4, has been shown to feedback and augment TLR4 signaling when over-produced in LPS hypersensitive gp130F/F mice. The identity of the LPS/TLR4 responsive inflammatory signaling pathways and gene networks which are modulated by IL6 ar...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29311 | biostudies-arrayexpress
TranscriptomicsTranscript Profiling of Elf5+/- Mammary Glands During Pregnancy Identifies Novel Targets of Elf5
Elf5, an epithelial-specific Ets transcription factor, plays a crucial role in the pregnancy-associated development of the mammary gland. However, the molecular mechanisms employed by Elf5 to exert its effects on the mammary gland are largely unknown. Transcript profiling was used to investigate th...
ORGANISM(S): Mus musculus 
2010-09-26 | E-GEOD-23373 | biostudies-arrayexpress
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