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ModelsChavez2009 - a core regulatory network of OCT4 in human embryonic stem cells
Chavez2009 - a core regulatory network of OCT4 in human embryonic stem cells A core OCT4-regulated network has been identified as a test case, to analyase stem cell characteristics and cellular differentiation. This model is described in the article: ...
2005-01-01 | MODEL1305010000 | BioModels
TranscriptomicsTranscription profiling of Ts65Dn vs control mice in nine different mouse tissues
To understand the molecular basis of Down syndrome pathogenesis, we performed a transcriptome analysis of nine different tissues in Ts65Dn, an established mouse model of human trisomy 21. Ts65Dn mice have segmental trisomy of mouse chromosome 16 with ca. 128 genes at dosage imbalance (Reeves et al. ...
ORGANISM(S): Mus musculus 
2004-04-23 | E-MEXP-102 | biostudies-arrayexpress
GenomicsDissection of the molecular complexity of colorectal cancer in pre-clinical models identifies predictive signatures of sensitivity to EGFR inhibitors
Colorectal carcinoma (CRC) is a heterogeneous tumour entity, with only a fraction of the tumours responding to currently available therapies. A detailed understanding of the biology and genetics of CRC is a prerequisite for precision medicine. To address this challenge in clinical oncology, the Onco...
EGAS00001001752 | EGA
GenomicsDAT_CancerMethodsPaper_SNVTumorFoci - samples
"Single nucleotide variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000035 | EGA
GenomicsDAT_CancerMethodsPaper_CNVTumorFoci - samples
"Copy number variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000036 | EGA
GenomicsDAT_CancerMethodsPaper_FFPE - samples
"SNV detection from formalin fixed paraffin embedded (FFPE) samples"
EGAD00001000033 | EGA
GenomicsDAT_CancerMethodsPaper_DNAAmounts - samples
"Usage of small amounts of DNA for Illumina sequencing"
EGAD00001000034 | EGA
Genomics"Targeted High Throughput Sequencing in Clinical Cancer Settings: Formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity"
"Background: Massively parallel sequencing technologies have brought an enormous increase in sequencing throughput. However, these technologies need to be further improved with regard to reproducibility and applicability to clinical samples and settings. Methods: Using identification of genetic var...
EGAS00001000136 | EGA
Genomics"Data Access Center Cancer Genomics Group"
Data Access Committee EGAC00001000030
EGAC00001000030 | EGA
TranscriptomicsEvaluation of the robustness of classification of carcinogen-modified transcriptomic responses in HepaRG cells and the interlaboratory reproducibility of the model
Efforts to develop alternatives which can at least partially replace some of the currently used in vivo tests are ongoing. The recently ended FP6 European project carcinoGENOMICS had the goal to use the combination of toxicogenomics and in vitro cell culture models for identification of genotoxic- a...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-48990 | biostudies-arrayexpress
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