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ProteomicsTargeted Protein Acetylation in Cells Using Heterobifunctional Molecules
Protein acetylation is a central event in orchestrating diverse cellular processes. However, current strategies to investigate protein acetylation in cells are often non-specific or lack temporal and magnitude control. Here, we developed an acetylation tagging system, AceTAG, to induce acetylation o...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD027617 | Pride
Targeted acetylation Acetylproteomics P300/cbp Heterobifunctional molecules 
GenomicsFunctional investigations of p53 acetylation enabled by heterobifunctional molecules
Functional investigations of p53 acetylation enabled by heterobifunctional molecules
PRJNA1158841 | ENA
Genomics
Depletion of malaria parasite targets using heterobifunctional molecules
PRJNA1175843 | ENA
UnknownLate-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation.
Not available
S-EPMC10716378 | biostudies-literature
UnknownCovalent 14-3-3 Molecular Glues and Heterobifunctional Molecules Against Nuclear Transcription Factors and Regulators.
Not available
S-EPMC10659333 | biostudies-literature
TranscriptomicsFunctional investigations of p53 acetylation enabled by heterobifunctional molecules
Post-translational modifications (PTMs) dynamically regulate the critical stress response and tumor suppressive functions of p53. Among these, acetylation events mediated by multiple acetyltransferases lead to differential target gene activation and subsequent cell fate. However, our understanding o...
ORGANISM(S): Homo sapiens 
2025-08-21 | GSE276776 | GEO
UnknownFunctional Investigations of p53 Acetylation Enabled by Heterobifunctional Molecules.
Not available
S-EPMC11421428 | biostudies-literature
GenomicsHeterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment
Heterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment
PRJNA1415116 | ENA
UnknownDegradation of the TEAD•YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules that Bind to the TEAD Allosteric Lipid Pocket.
Not available
S-EPMC12803072 | biostudies-literature
TranscriptomicsHeterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment
Non-catalytic heterobifunctional molecules promise to expand the range of therapeutic options by establishing complexes between key target proteins and accessory presenter proteins equipped with additional properties. Here, we systematically investigate the rational design of such molecules, explore...
ORGANISM(S): Homo sapiens 
2026-07-10 | GSE317727 | GEO
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