Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: Li Yun Chen
LAB HEAD: Christopher G. Parker
PROVIDER: PXD027617 | Pride | 2024-01-26
REPOSITORIES: Pride
Journal of the American Chemical Society 20210930 40
Protein acetylation is a central event in orchestrating diverse cellular processes. However, current strategies to investigate protein acetylation in cells are often nonspecific or lack temporal and magnitude control. Here, we developed an acetylation tagging system, AceTAG, to induce acetylation of targeted proteins. The AceTAG system utilizes bifunctional molecules to direct the lysine acetyltransferase p300/CBP to proteins fused with the small protein tag FKBP12<sup>F36V</sup>, resulting in t ...[more]