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ProteomicsHeterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells
The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the phenotype of tumoral cells and have significant implications in cancer development and progression. In this study we performed an in vitro heterotypic signaling assay by evaluating the prot...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD020426 | Pride
Cancer-associated fibroblasts Heterotypic signaling Fibroblast Phenotypic plasticity. Melanoma 
UnknownA direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to β-catenin.
Not available
S-EPMC6923138 | biostudies-literature
ProteomicsProximity labelling and SILAC based proteomic approach identifies proteins at the interface of homotypic and heterotypic cancer cell interactions.
Cell-cell interactions are critical for the growth of organisms and maintaining homeostasis. In the tumor microenvironment, these interactions promote cancer progression. Given their importance in healthy and diseased conditions, we have developed a method to analyze the cell-to-cell interactome. Ou...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD052917 | Pride
Silac based  proteomics Nano lc-ms/ms orbitap Cell-cell interactions 
ProteomicsProximity labelling and SILAC based proteomic approach identifies proteins at the interface of homotypic and heterotypic cancer cell interactions.
Cell-cell interactions are critical for the growth of organisms and maintaining homeostasis. In the tumor microenvironment, these interactions promote cancer progression. Given their importance in healthy and diseased conditions, we have developed a method to analyze the cell-to-cell interactome. Ou...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD052746 | Pride
Silac based Orbitrap Hrp Cell-cell interactions 
ProteomicsProximity labelling and SILAC based proteomic approach identifies proteins at the interface of homotypic and heterotypic cancer cell interactions.
Cell-cell interactions are critical for the growth of organisms and maintaining homeostasis. In the tumor microenvironment, these interactions promote cancer progression. Given their importance in healthy and diseased conditions, we have developed a method to analyze the cell-to-cell interactome. Ou...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD060134 | Pride
Silac based  proteomics Nano lc-ms/ms orbitap Cell-cell interactions 
UnknownHeterotypic gap junction channels as voltage-sensitive valves for intercellular signaling.
Not available
S-EPMC2736430 | biostudies-literature
UnknownCabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors.
Not available
S-EPMC7352584 | biostudies-literature
GenomicsYAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
PRJNA526203 | ENA
GenomicsYAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
PRJNA526205 | ENA
GenomicsYAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
PRJNA526207 | ENA
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