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ProteomicsNormal respiratory chain capacity and physiology in mice with severely reduced levels of mitochondrial respirasomes; Cross-linking of intact mitochondria
The mammalian oxidative phosphorylation (OXPHOS) system in the inner mitochondrial membrane comprises respiratory chain complexes I-IV (CI-CIV) and ATP synthase. Together, these protein complexes harvest metabolic energy to generate ATP, the cellular energy currency. The inner mitochondrial membrane...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD031345 | Pride
Cross-linking mass spectrometry (cx-ms) 
Proteomics"In-gel cross-linking mass spectrometry (IGX-MS) of proteins and protein complexes"
Cross-linking mass spectrometry has developed into an important method to study protein structures and interactions. The in-solution cross-linking workflows involve time and sample consuming steps and do not provide sensible solutions for differentiating cross-links obtained from co-occurring protei...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Escherichia coli 
2020-12-14 | PXD020014 | Pride
Bn-page/ cross-linking/ protein complexes/ complement/ protein modeling 
ProteomicsHAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD028415 | Pride
Saxs Huntingtin Xl-ms Cryo-em Integrative modeling 
ProteomicsHAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD028313 | Pride
Saxs Huntingtin Xl-ms Cryo-em Integrative modeling 
ProteomicsMRPS36 provides a missing link in the eukaryotic 2-oxoglutarate dehydrogenase complex for recruitment of E3 to the E2 core - Phospoproteomics data
The tricarboxylic acid (TCA) cycle, or Krebs cycle, is the central pathway of energy production in eukaryotic cells and plays a key part in aerobic respiration throughout all kingdoms of life. The enzymes involved in this cycle generate the reducing equivalents NADH and FADH2 by a series of enzymati...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-10 | PXD036896 | Pride
2-oxoglutarate dehydrogenase (ogdhc)  mrps36  tricarboxylic acid (tca) cycle  krebs cycle  heart mitochondria  cross-linking mass spectrometry  complexome profiling  structural biology  comparative genomics 
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