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TranscriptomicsGenome-wide DNA methylation profiling of Progeria and Werner syndrome patients
DNA methylation gradiently changes with age and is likely to be involved in aging-related processes resulting in phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria Syndrome (HGP) and Werner Syndrome are two premature aging diseases showing features of...
ORGANISM(S): Homo sapiens 
2013-01-14 | E-GEOD-42865 | biostudies-arrayexpress
TranscriptomicsThe DNA Methylomes of a Newborn and a Centenarian
Examination of two DNA methylomes at the most extreme points of their lives to see differences that might contribute to explain the aged phenotype We have performed Whole Genome Bisulfite Sequencing (WGBS) and methylation array technology of newborn and a centenarian samples to address the Epigeneti...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-31438 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation aberrations in human atherosclerosis (sequencing)
Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it func...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-46327 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling in breast cancer discordant identical twins
We obtained a comprehensive DNA methylation profile of 15 breast cancer discordant twins, using the high resolution Infinium HumanMethylation450 BeadChip platform (450K, Illumina), previously established to reliably detect methylation changes of more than 450,000 CpG sites. To provide insight into t...
ORGANISM(S): Homo sapiens 
2012-10-17 | E-GEOD-37965 | biostudies-arrayexpress
TranscriptomicsDNA methylation differences between Newborns and Nonagenarians [PBMNC]
Human aging implies many phenotypic modifications and an increased susceptibility to many common diseases, phenomena that cannot be fully explained by the constrained genetic setting. An alternative pathway that could explain the age-associated alterations is epigenetic drifts. To address this issue...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-33233 | biostudies-arrayexpress
GenomicsGenome-wide profiling of the DNA methylation landscape in primary and matastatic breast cancer types [468LN and 468PT]
Whole genome bisulphite sequencing of 2 human breast cancer cell lines representing a breast primary tumor and a matched lymph node metastasis. Sequencing of bisulfite converted DNA of cancer cell line samples.
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-56763 | biostudies-arrayexpress
TranscriptomicsDNA methylomes of Newborns and Nonagenarians
DNA methylation differences between Newborns and Nonagenarians The study aimed to compare the DNA methylation differences between newborns and nonagenarians using methylation array technology (450K, Illumina). The identified differently methylated CpG were further analyzed for their presence in dise...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-30870 | biostudies-arrayexpress
GenomicsThe DNA methylomes of a newborn and a centenarian
We have developed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and a centenarian to address the epigenetic drifts in human aging, which might be an alternative pathway to explain the age-associated alterations. In addition, we have analyzed the methylome of a middle-age donor (26 years). Ex...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-31263 | biostudies-arrayexpress
GenomicsMus musculus
Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration
PRJNA280215 | ENA
GenomicsEpigenetic alterations of a DNMT3B-mutant ICF patient at base-pair resolution
The immunodeficiency, centromere instability and facial anomalies (ICF) syndrome is associated with mutation of the DNA methyl-transferase DNMT3B, resulting in a reduction of enzyme activity. Aberrant expression of immune system genes and hypomethylation of pericentromeric regions accompanied by chr...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37578 | biostudies-arrayexpress
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