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ProteomicsHflX mediates rifampicin resistance in Brucella by downregulating the expression of RNA polymerase-associated genes
To further investigate molecular changes associated with HflX knock during rifampicin exposure, we performed label-free quantitative proteomic analysis. The WT and ΔhflX strains were cultured for three generations in the presence of 1/2 MIC rifampicin (1 μg/mL) and harvested during the logarithmic g...
ORGANISM(S): Brucella Abortus 2308 
2026-03-19 | PXD075846 |
UnknownMycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance.
Not available
S-EPMC6955381 | biostudies-literature
UnknownHflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.
Not available
S-EPMC11831132 | biostudies-literature
UnknownCharacterization of the autophosphorylation property of HflX, a ribosome-binding GTPase from Escherichia coli.
Not available
S-EPMC4932445 | biostudies-literature
UnknownHflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria.
Not available
S-EPMC8000101 | biostudies-literature
UnknownThe universally conserved GTPase HflX is an RNA helicase that restores heat-damaged Escherichia coli ribosomes.
Not available
S-EPMC6028529 | biostudies-literature
UnknownThe conserved GTPase HflX is a ribosome splitting factor that binds to the E-site of the bacterial ribosome.
Not available
S-EPMC4770234 | biostudies-literature
UnknownNovel MntR-independent mechanism of manganese homeostasis in Escherichia coli by the ribosome-associated protein HflX.
Not available
S-EPMC4097593 | biostudies-literature
UnknownIdentification and characterization of a hitherto unknown nucleotide-binding domain and an intricate interdomain regulation in HflX-a ribosome binding GTPase.
Not available
S-EPMC3814362 | biostudies-literature
UnknownTime resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling.
Not available
S-EPMC10872292 | biostudies-literature
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