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ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Recent data have shown that Hypermethylated in cancer 1 (HIC1) is an important contributor to iTreg cell development and function. Using affinity-purification and tandem mass spectrometry we systematically characterized the HIC-1 interactome in human iTreg cells. On the basis of these data, we have ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD039337 | Pride
Hic1  interactome  immunoprecipitation  proteomics  foxp3  protein complex  runx1  regulatory t cells  t cell differentiation  tgf-β  treg  itreg. 
TranscriptomicsGene expression in human breast cancer cell lines regulated by HIC1 gene
This study aimed to further our understanding of the role that hypermethylatioted in cancer 1 (HIC1) plays in breast cancer progression. Microarrays were searched for some genes that had correlated expression with HIC1 mRNA. According to fold-change screening between restoring expression of HIC1 and...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-50061 | biostudies-arrayexpress
TranscriptomicsGene expression in human prostate cancer cell lines regulated by HIC1 gene
This study aimed to further our understanding of the role that hypermethylatioted in cancer 1 (HIC1) plays in prostate cancer (PCa) development. Microarrays were searched for some genes that had correlated expression with HIC1 mRNA. Our data showed that HIC1 promoter hypermethylation was presented i...
ORGANISM(S): Homo sapiens 
2012-11-17 | E-GEOD-42336 | biostudies-arrayexpress
TranscriptomicsEffect of HIC1 and miR-212/132 expression on MCF7 cells
To identify the target of miR-212, miR-132 and HIC1, we have employed whole genome microarray expression profiling on the human breast cancer MCF7 cells. To generate miR-212/132 or HIC1 inducible MCF7 cells, doxycycline-dependent miR-212/132 or HIC1 gene expression system was used. Either Tet-ON miR...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-37945 | biostudies-arrayexpress
GenomicsCharacterization of E13.5 forelimb gene expression after Hic1 knockout
Characterization of E13.5 forelimb gene expression after Hic1 knockout
PRJNA940043 | ENA
TranscriptomicsLoss of Hic1 tumor suppressor potentiates Tlr2/NF-kB signaling and promotes tissue damage-associated tumorigenesis in the colon.
Hypermethylated in cancer 1 (HIC1) represents a prototypic tumor suppressor gene frequently inactivated by DNA methylation in many types of solid tumors. The gene encodes a sequence-specific transcriptional repressor controlling expression of several genes involved in the cycle or stress control. In...
ORGANISM(S): Mus musculus 
2016-02-01 | E-MTAB-3486 | biostudies-arrayexpress
UnknownHypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.
Not available
S-EPMC5356670 | biostudies-literature
TranscriptomicsU2OS ad-HIC1 target identification
The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1) is essential for mammalian development and is epigenetically silenced in many human tumors. Functionally, HIC1 is involved in a complex pathway regulating P53 tumor-suppression activity. HIC1 encodes a sequence-specific transcriptional rep...
ORGANISM(S): Homo sapiens 
2007-12-13 | GSE9854 | GEO
GenomicsGene expression in PC3 cells(human prostate cancer cell line) upon HIC1 knockout
Gene expression in PC3 cells(human prostate cancer cell line) upon HIC1 knockout
PRJNA594285 | ENA
UnknownHIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy.
Not available
S-EPMC4833890 | biostudies-literature
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