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MetabolomicsSacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
Dietary ω-3 polyunsaturated fatty acids (PUFAs) are beneficial for humans against the development of hyperlipidaemia, but the underlying mechanisms are still poorly understood. Here, we demonstrated that oral consumption of sacha inchi oil, which is rich in α-linolenic acid, alleviated dyslipidemia,...
2022-02-21 | MTBLS1225 | MetaboLights
MetabolomicsComprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart
The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet a...
2015-11-17 | MTBLS173 | MetaboLights
MetabolomicsThe Effects of Combined Aerobic and Resistance Exercise on Liver Metabolomics in Mice Fed a High-Fat Diet

Background and Objectives: Obesity is often accompanied by hepatic metabolic disorders and chronic low-grade inflammation. While combined aerobic and resistance exercise is considered an intervention to improve body composition, its systematic regulatory effects on the hepatic metabolic profile r...

2026-07-11 | MTBLS15011 | MetaboLights
MetabolomicsDietary Cetobacterium somerae LY-01 improves lipid metabolism and intestinal health in largemouth bass (Micropterus salmoides) fed a high-fat diet
Non-targeted metabolomics sequencing was performed on the control group diet (C), the high-fat group diet (H), and the high-fat + Cetobacterium somerae LY-01 (HCS9) diet to investigate their effects on intestinal health.
2026-09-03 | MTBLS15536 | MetaboLights
TranscriptomicsHepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet
Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expresse...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-64824 | biostudies-arrayexpress
ProteomicsProteomic Analyses of Cysteine Redox in High-fat-fed and Fasted Mouse Livers: Implications for Liver Metabolic Homeostasis
Intensive oxidative stress occurs during high-fat-diet-induced hepatic fat deposition, suggesting a critical role for redox signaling in liver metabolism. Intriguingly, lines of evidence show that fasting could also result in redox profile changes, largely through reduced oxidant and/or increased an...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-03 | PXD006612 | Pride
Proteomic High-fat-fed 
TranscriptomicsTranscription profiling by array of eWAT from CD1 WT and Irx5-KO mice fed a high fat diet
The aim was to compare the global gene expression of epididymal white adipose tissue (eWAT) of WT and Irx5-KO mice. Mice 10 weeks of age were fed a high-fat diet for 10 weeks before eWAT was dissected out, RNA extracted and microarray performed
ORGANISM(S): Mus musculus 
2018-12-12 | E-MTAB-6726 | biostudies-arrayexpress
TranscriptomicsBeta cell overexpression of HSD11B1 in high fat fed mice
To model the potential diabetogenic effects of higher level of HSD11B1 in b-cells of the pancreas in vivo, we created a transgenic model overexpressing HSD11B1 under the mouse insulin I promoter (MIP-HSD1) in diabetes-prone C57Bl/KsJ mice. KsJ wild type and MIP-HSD1 heterozygous mice have been high ...
ORGANISM(S): Mus musculus 
2011-06-30 | E-GEOD-23161 | biostudies-arrayexpress
TranscriptomicsExpression data from the adipose tissue of mice fed a normal diet and a high fat diet.
To identify novel Peroxisome Proliferator-Activated Receptor gamma (PPARg) responsive secretory and/or transmembrane genes that is related to obesity, we integrated the expression data from the adipose tissue derived from obese mice with the other two data sets: expression profiling of adipocyte dif...
ORGANISM(S): Mus musculus 
2013-01-30 | E-GEOD-36492 | biostudies-arrayexpress
TranscriptomicsEffect of deletion of liver Mitofusin 1 (Mfn1) on energy metabolism in high fat diet fed mice
Microarray analysis of the livers from Mfn1 WT and Mfn1 LKO mice fed with high fat diet. We hypothesised that deletion of Mfn1 will lead reduced mitochondrial fusion thus leading to an increase in the number of smaller but higher functional mitochondria and increase in mitochondrial proteins. Total ...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-74888 | biostudies-arrayexpress
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