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TranscriptomicsGene expression profiles of livers from mice fed high-fat diet and high fructose-glucose solution for 8 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67678 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers and liver tumors from mice fed high-fat diet and high fructose-glucose solution for 52 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67679 | biostudies-arrayexpress
TranscriptomicsGene expression data from liver of rat fed a high-fat diet and high-fructose water without/with Eucommia ulmoides leaves
To investigate effects of intake of Eucommia ulmoides leaves on hyperlipidemia, we performed gene expression profiling on rat liver by microarray analysis. Microarray analysis revealed that Eucommia ulmoides leaves up-regulated the gene expression involved in alpha-, beta-, and omega-oxidation of fa...
ORGANISM(S): Rattus norvegicus 
2011-08-21 | E-GEOD-24377 | biostudies-arrayexpress
ProteomicsHigh Fructose-Driven Epigenetic and Metabolic Reprogramming in Glomerular Podocyte
High fructose diet has been proposed as a major contributor to metabolic syndrome, which is usually accompanied with proteinuria due to glomerular podocyte injury. However, the underlying pathological mechanisms of fructose-induced podocyte injury remain elusive. In this study, we have used an iTRAQ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-19 | PXD017849 | Pride
Itraq Rat High-fructose diet Podocyte injury Epigenetic mechanism. Mitochondria dysfunction Metabolic reprogramming 
TranscriptomicsHepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet
Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expresse...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-64824 | biostudies-arrayexpress
GenomicsMouse liver FLCN gRNA on high fat/high fructose diet
Mouse liver FLCN gRNA on high fat/high fructose diet
PRJNA1463790 | ENA
TranscriptomicsIdentification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity
Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers. Fetal he...
ORGANISM(S): Papio hamadryas 
2013-02-01 | E-GEOD-43323 | biostudies-arrayexpress
MetabolomicsThe Effects of Combined Aerobic and Resistance Exercise on Liver Metabolomics in Mice Fed a High-Fat Diet

Background and Objectives: Obesity is often accompanied by hepatic metabolic disorders and chronic low-grade inflammation. While combined aerobic and resistance exercise is considered an intervention to improve body composition, its systematic regulatory effects on the hepatic metabolic profile r...

2026-07-11 | MTBLS15011 | MetaboLights
GenomicsEfffect of a high fructose diet on gene expression in vervet monkey livers.
Efffect of a high fructose diet on gene expression in vervet monkey livers.
PRJNA736731 | ENA
GenomicsEfffect of a high fructose diet on miRNA expression in vervet monkey livers
Efffect of a high fructose diet on miRNA expression in vervet monkey livers
PRJNA738169 | ENA
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