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TranscriptomicscaArray_hanas-00078: Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis
Astrocytomas are heterogeneous intracranial glial neoplasms ranging from the highly aggressive malignant glioblastoma multiforme (GBM) to the indolent, low-grade pilocytic astrocytoma. We have investigated whether DNA microarrays can identify gene expression differences between high-grade and low-gr...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-70231 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of high and low grade gliomas from human patients to identify new diagnostic and prognostic markers
Comparison of high grade to low grade gliomas.
ORGANISM(S): Homo sapiens 
2007-06-01 | E-TABM-167 | biostudies-arrayexpress
TranscriptomicsNovel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
The outcome for children with high-grade gliomas (HGG) remains dismal, with a two-year survival rate of only 10-30%. Approximately half of pediatric HGGs are diffuse intrinsic pontine glioma (DIPG), a brainstem tumor that arises almost exclusively in children. Genome-wide analyses of copy number i...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46190 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of high grade gliomas arising in children and young people
As genome-scale technologies begin to unravel the complexity of the equivalent tumours in adults, detailed characterisation of high grade gliomas in children have until recently been lacking. In order to validate and extend investigations of the differences between paediatric and adult tumours, we c...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-TABM-857 | biostudies-arrayexpress
TranscriptomicsIntegrated molecular genetic profiling of pediatric-high grade gliomas reveals key differences with adult disease
Purpose: To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). Patients and Methods: We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGG, including 7 diffuse intrinsic pontine gliomas, and 10 HGG cases ar...
ORGANISM(S): Homo sapiens 
2010-06-15 | E-GEOD-19578 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Sunitinib-treated but not untreated short-term serum-free cultures predict treatment response of human high-grade gliomas in vitro
High-grade gliomas are amongst the most deadly human tumors. Treatment results are overall disappointing. Nevertheless, in several trials around 20% of patients respond to therapy. Diagnostic strategies to identify those patients that will ultimately profit from a specific targeted therapy are urgen...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-51305 | biostudies-arrayexpress
ProteomicsMultiple reaction monitoring based targeted validation of over-expressed proteins of high-grade gliomas
High-grade gliomas (HGGs) are extremely aggressive primary brain tumors with high mortality rates. Despite notable advancements in clinical research, HGGs are still characterized by poor prognosis and appalling survival rates. Several global proteomics studies have reported many protein biomarkers h...
ORGANISM(S): Homo Sapiens 
PXD043621 | panorama
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-7804 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-09 | E-MTAB-7802 | biostudies-arrayexpress
TranscriptomicsIllumina Infinium HumanMethylation450 BeadChip profiling of paediatric high grade gliomas and diffuse intrinsic pontine gliomas
We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas and diffuse intrinsic pontine gliomas. The 450K methylation array is being used to separate brain tumour samples on the basis of their methylation profiles which represent the cell of...
ORGANISM(S): Homo sapiens 
2017-09-28 | E-MTAB-5528 | biostudies-arrayexpress
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