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TranscriptomicsTranscriptomic analysis of the osmotic and reproductive remodelling of the female rat supraoptic nucleus
The supraoptic nucleus (SON) of the hypothalamus is an important integrative brain structure that co-ordinates responses to perturbations in water balance and regulates maternal physiology through the release of the neuropeptide hormones vasopressin and oxytocin into the circulation. Both dehydratio...
ORGANISM(S): Rattus norvegicus 
2011-12-29 | E-GEOD-30733 | biostudies-arrayexpress
TranscriptomicsNIA Neuroarray dehydration
The magnocellular neurons (MCNs) of the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus are the principal site of biosynthesis of prepropeptide precursor of the antidiuretic hormone vasopressin (VP). This precursor is processed during anterograde axonal transportation ...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-3133 | biostudies-arrayexpress
TranscriptomicsSSH-PCR dehydrated supraoptic nucleus
The magnocellullar neurons (MCNs) of the supraoptic nucleus (SON) of the hypothalamus are the principle source of the neuropeptide hormone vasopressin (VP), which has a crucial role in osmoregulation. Physiological activation of the SON by dehydration results is a massive release of VP from stores i...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-3132 | biostudies-arrayexpress
TranscriptomicsHypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expression but conserved pathways
We have addressed the question of how different rodent species cope with the life-threatening homeostatic challenge of dehydration at the level of transcriptome modulation in the supraoptic nucleus (SON), a specialised hypothalamic neurosecretory apparatus responsible for the production of the antid...
ORGANISM(S): Mus musculus 
2010-11-29 | E-GEOD-25574 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat supraoptic nucleus in euhydrated and dehydrated rats.
The hypothalamo-neurohypophyseal system (HNS) is crucial for osmoregulation. The HNS consists of the magnocellular neurons (MCNs) of the hypothalamus that have their axons terminating in the posterior pituitary. The HNS exerts its role in water balance via the release of the anti-diuretic hormone va...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3131 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hypothalamic paraventricular (PVN)nuclei in euhydrated and dehydrated animals
The hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei are important integrative structures that regulate co-ordinated responses to perturbations in cardiovascular homeostasis. Through descending projections from parvocellular neurons to the brainstem, the PVN acts as an autonomic 'p...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3111 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hypothalamo-neurohypophyseal system in euhydrated and dehydrated animals
The hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei are important integrative structures that regulate co-ordinated responses to perturbations in cardiovascular homeostasis. Through descending projections from parvocellular neurons to the brainstem, the PVN acts as an autonomic 'p...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3110 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neurointermediate lobe in euhydrated and dehydrated animals
The hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei are important integrative structures that regulate co-ordinated responses to perturbations in cardiovascular homeostasis. Through descending projections from parvocellular neurons to the brainstem, the PVN acts as an autonomic 'p...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3125 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Rattus norvegicus hypothalamoneurohypophyseal system from euhydrated and dehydrated animals
This SuperSeries is composed of the following subset Series:; GSE3110: Comprehensive description of the transcriptome of hypothalamo-neurohypophyseal system in euhydrated and dehydrated rat; GSE3111: Comprehensive description of the transcriptome of PVN in euhydrated and dehydrated rat; GSE3125: Com...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-4130 | biostudies-arrayexpress
TranscriptomicsExcessive leukotriene B4 in nucleus tractus solitarii is pro-hypertensive in spontaneously hypertensive rats.
We have used Affymetrix microarray-driven gene profiling to comprehensively describe the expression of mRNAs in the nucleus tractus solitarii (NTS) in the adult male spontaneously hypertensive rat (SHR) as compared to its normotensive parental Wistar-Kyoto (WKY) strain. Keywords: Gene expression ...
ORGANISM(S): Rattus norvegicus 
2013-03-01 | E-GEOD-8796 | biostudies-arrayexpress
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