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MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
ProteomicsPatient-based model systems for AD
The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of AD pathog...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-10-24 | PXD042229 | Pride
Hippocampus Hippocampal graft Alzheimers disease 
UnknownHippocampal Neural Stem Cell Grafting after Status Epilepticus Alleviates Chronic Epilepsy and Abnormal Plasticity, and Maintains Better Memory and Mood Function.
Not available
S-EPMC7673840 | biostudies-literature
UnknownProteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer's disease pathogenesis.
Not available
S-EPMC10504768 | biostudies-literature
UnknownGABAergic Progenitor Cell Graft Rescues Cognitive Deficits in Fragile X Syndrome Mice.
Not available
S-EPMC11904963 | biostudies-literature
UnknownHuman Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease.
Not available
S-EPMC6915849 | biostudies-literature
UnknownDefining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.
Not available
S-EPMC4275007 | biostudies-literature
TranscriptomicsHuman iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease
Young blood or plasma and young bone marrow improves cognitive function in aged animals, though the cell type responsible for these regenerative effects remains unknown. The current study used induced pluripotent stem cells (iPSCs) to assess the potential of mononuclear phagocytes as a therapeutic f...
ORGANISM(S): Mus musculus 
2025-09-10 | GSE220548 | GEO
TranscriptomicsDonor bone marrow-derived macrophage MHC II drives neuroinflammation and cognitive deficits during chronic GVHD in mice
Graft-versus-host disease (GVHD) remains the leading cause of non-relapse mortality after allogeneic stem cell transplantation for haematological malignancies. Manifestations of GVHD in the central nervous system (CNS) present as neurocognitive dysfunction in up to 60% of patients, however, the mech...
ORGANISM(S): Mus musculus 
2021-08-18 | GSE179441 | GEO
UnknownNeural Stem Cell or Human Induced Pluripotent Stem Cell-Derived GABA-ergic Progenitor Cell Grafting in an Animal Model of Chronic Temporal Lobe Epilepsy.
Not available
S-EPMC5313261 | biostudies-literature
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