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TranscriptomicsInventory of genes expressed in human control hippocampus
Serial analysis of gene expression (SAGE) was used to get a global view of the gene profile in human hippocampus. A library were generated from control hippocampus, obtained by rapid autopsy. Keywords: hippocampus human inventory genes Control hippocampus (used to construct the SAGE control library)...
ORGANISM(S): Homo sapiens 
2005-12-29 | E-GEOD-3928 | biostudies-arrayexpress
ProteomicsTMT-labeled quantitative protein profiling of hippocampus during human aging
Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080710 | MassIVE
no omics definedTranscription profiling of human hippocampi from epilepsy patients with and without hippocampal sclerosis and autopsy controls
Genome wide gene expression was compared between nonHS, HS temporal lobe epilepsy patients (TLE) and autopsy control hippocampi in a 3-way analysis. In many TLE patients the hippocampus is subject to massive neuronal damage, gliosis and hippocampal sclerosis (HS), while in others there is no apparen...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-MEXP-744 | biostudies-arrayexpress
ProteomicsProteomic profile of hippocampus regions from the pilocarpine medial temporal lobe epilepsy model
Label-free Proteomic profile of the dentate gyrus (dorsal and ventral) and CA3 (dorsal and ventral) microdissected from the hippocampus of the pilocarpine model of Mesial Temporal Lobe Epilepsy.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2024-03-25 | MSV000094401 | MassIVE
TranscriptomicsTranscription profiling of mouse laser dissected hippocampus of Rasgrf1 knockout mice
We used manual macrodissection or laser capture microdissection (LCM) to isolate tissue sections of the hippocampus area of Ras-GRF1 wild type and knockout mice brains, and analyzed their transcriptional patterns using commercial oligonucleotide microarrays. Comparison between the transcriptomes of ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8425 | biostudies-arrayexpress
TranscriptomicsHT-project: Expression profiling after prolonged experimental febrile seizures suggests structural remodeling in the hippocampus
Febrile seizures are the most prevalent type of seizures among children up to 5 years of age (2-4% of Western-European children). Complex febrile seizures are associated with an increased risk to develop temporal lobe epilepsy. To investigate short- and long-term effects of experimental febrile seiz...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-66762 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hippocampus from wild type and ZIF268(Egr1) knock-out mice subjected to kainic acid induced seizures
ZIF268(Egr1) KO mice and wild type littermate subjected KA induced seizure and the hippocampus subregion isolated 2hrs later
ORGANISM(S): Mus musculus 
2008-12-29 | E-MEXP-1483 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human motor cortex in sporadic amyotrophic lateral sclerosis
We used oligonucleotide microarrays to find differentially expressed genes between control subjects and those affected by sporadic amyotrophic lateral sclerosis. Experiment Overall Design: Complementary RNAs (cRNAs) labelled with Cy5-CTP (Perkin-Elmer) were synthesized from 1 µg of total RNA of eac...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4595 | biostudies-arrayexpress
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hippocampus treated with kainate to induce seizures - time series
Mesial temporal lobe epilepsy (MTLE) is the most common medically refractory epilepsy syndrome; kainic acid (KA) induced seizures have been studied as a MTLE model as limbic seizures produced by systemic injections of KA result in a distinctive pattern of neurodegeneration in the hippocampus that re...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1834 | biostudies-arrayexpress
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