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UnknownA randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer.
Not available
S-EPMC3179254 | biostudies-literature
TranscriptomicsENCODE: p63ActD & p63_mActD ChIP of retinoic acid-stimulated ME180 cells at 0 h (NCBIv35) - strict analysis parameters
p63 with and without actinomycin D treatment ChIP from retinoic acid stimulated ME180 Cells at 0 hours using Affymetrix ENCODE tiling chip with NCBI build 35 annotation. p63_ActD and p63_mActD ChIP from retinoic acid stimulated ME180 Cells, 0 hours.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-3661 | biostudies-arrayexpress
TranscriptomicsA Transcriptional Signature and Common Gene Networks Link Cancer with Metabolic Syndrome and Auto-immune Diseases
Epidemiological studies have revealed concurrence of specific cancers with other disease states such as metabolic syndrome, inflammatory disease and autoimmune disease. Patients with these chronic conditions have a higher incidence of various cancers, more aggressive tumors, and a higher mortality r...
ORGANISM(S): Homo sapiens 
2010-04-19 | E-GEOD-17941 | biostudies-arrayexpress
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR) [RNA-seq]
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-47997 | biostudies-arrayexpress
UnknownUltra-Widefield and Early Treatment Diabetic Retinopathy Study 7-Field Grading of Diabetic Retinopathy.
Not available
S-EPMC11327899 | biostudies-literature
ProteomicsTripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation
The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated CaV1.2 channels, is of great physiological and pathophysiological importance. Stimulation of β-adrenergic receptors (βAR) activates protein kinase A (PKA) through separation of regulatory (PK...
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD057841 | Pride
Calcium channel  protein‐protein interaction  adrenergic regulation  cardiac  protein kinase a (pka)  heterologous expression 
UnknownRadiation Oncology AcaDemic Mentorship Program (ROADMAP) for Junior Faculty: One-Year Results of a Prospective Single Institution Initiative.
Not available
S-EPMC9396442 | biostudies-literature
TranscriptomicsA novel way for enriching human melanoma precursor cells to identify cellular targets for antineoplastic therapy
Metastatic melanoma is difficult to treat and is resistant to most current therapies. We hypothesized that stem cell related pathways may play a role in melanoma growth since stem cells and cancer cells share essential properties. Lately, the ABC transporter, ABCB5, as well as Cripto-1, CD20, CD133...
ORGANISM(S): Homo sapiens 
2011-12-29 | E-GEOD-20469 | biostudies-arrayexpress
TranscriptomicsComparison of post-mortem tissue from brain BA10 region between schizophrenic and control patients.
Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong...
ORGANISM(S): Homo sapiens 
2009-08-13 | E-GEOD-17612 | biostudies-arrayexpress
UnknownA phase I/II study of erlotinib in combination with the anti-insulin-like growth factor-1 receptor monoclonal antibody IMC-A12 (cixutumumab) in patients with advanced non-small cell lung cancer.
Not available
S-EPMC3358820 | biostudies-literature
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