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ProteomicsChemical derivatization of histones for LC-MS/MS analysis
Histone lysine methylation is an important post-translational modifications (PTMs) that plays critical roles in numerous biological processes with abnormal histone lysine methylation having been associated with developmental defects and human diseases. The primary amine of all lysine residues can be...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028269 | Pride
Dimethyl labeling Propionylation Histone Histione methylation 
ProteomicsHistione HCD and CID datasets for evaluation of search engines
To identify confident spectra from histone peptides containing PTMs, we present a method in which one kind of modification is searched each time. We then combine the identifications of multiple search engines to obtain confident results. We find that two search engines, pFind and Mascot, identify mo...
ORGANISM(S): Homo sapiens (Human) 
2014-09-01 | PXD001118 | Pride
Proteomics Search engine Post-translational modification Data analysis Histone 
TranscriptomicsCalactin - a small molecule induces DNA damage and histione modification in leukemia cells
Calactin is a small molecule isolated from the Chinese herb Asclepias curassavica. We found that calactin induced DNA damage, G2/M arrest of cell cycle, and apoptosis. The calactin also increased the H2AX and Chk2 phosphorylation, which resulted in the decrease of Cdc25C and cdk1 expressions, indica...
ORGANISM(S): Homo sapiens 
2011-03-31 | GSE20928 | GEO
TranscriptomicsCalactin - a small molecule induces DNA damage and histione modification in leukemia cells
Calactin is a small molecule isolated from the Chinese herb Asclepias curassavica. We found that calactin induced DNA damage, G2/M arrest of cell cycle, and apoptosis. The calactin also increased the H2AX and Chk2 phosphorylation, which resulted in the decrease of Cdc25C and cdk1 expressions, indica...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-20928 | biostudies-arrayexpress
GenomicsHomo sapiens
Calactin - a small molecule induces DNA damage and histione modification in leukemia cells
PRJNA124367 | ENA
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