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ProteomicsAtlas of lysine propionylation in the human right atrium reveals ALDH6A1-NADH pathway involved in the new-onset atrial fibrillation in aging after coronary artery bypass grafting
Lysine propionylation modification (Kpr) plays an important role in the pathogenesis of several cardiovascular diseases, but the role of Kpr in postoperative atrial fibrillation (POAF) is unclear. Here, we established an atlas of proteomics and propionylation proteomics in the atrial appendage tissu...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD059607 | Pride
Propionylation Aldh6a1 Atrial fibrillation Coronary artery bypass grafting 
ProteomicsImproved Mass Spectrometry-based methods to study histone propionylation
Histone post-translational modifications (PTMs) have crucial roles in a multitude of cellular processes, their aberrant levels have been linked with numerous diseases, including cancer. Although histone PTM investigations have focused so far on methylations and acetylations, alternative long-chain a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-07-11 | PXD050362 | Pride
Histone post-translational modifications Propionylation Acylation 
ProteomicsSample preparation procedure for mass spectrometric analysis of plant histones
The protocol for preparing samples of plant histones prior to LC-MS/MS analysis was established, using a filter-aided sample preparation (FASP) technique to remove natural contaminants and chemical additives incompatible with MS-based procedures. The protocol consists of nuclei isolation, histone ex...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-09-20 | PXD010102 | Pride
Arabidopsis thaliana Mass spectrometry Post-translational modifications Epigenetics Histone derivatization Filter-aided sample preparation 
UnknownA Transfer Learning-Based Approach for Lysine Propionylation Prediction.
Not available
S-EPMC8096918 | biostudies-literature
UnknownPropionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish.
Not available
S-EPMC8188496 | biostudies-literature
ProteomicsDisrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
Propionate is a common three-carbon intermediate produced from the breakdown of propiogenic substrates, such as branched-chain amino acids and odd-numbered fatty acids, and by gut bacteria. Propionate can chemically modify proteins, and if this involves histones, it may underpin a disease-relevant l...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-09-29 | PXD043513 | Pride
Heart failure Histone Contraction Epigenetics Propionic acidemia 
UnknownLysine propionylation is a prevalent post-translational modification in Thermus thermophilus.
Not available
S-EPMC4159656 | biostudies-literature
ProteomicsProtein propionylation in Pcca deficiency
To determine the prevalence and identify any enrichment of lysine propionylation in PCC deficiency, an analysis comparing the propionylated liver proteins of control and liver-specific Pcca knockout mice was performed. Liver-specific knockout of PCC activity was induced in mice with floxed axons for...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-09 | PXD076266 | Pride
Mouse Liver Nano lc-ms/ms 
UnknownPitfalls in histone propionylation during bottom-up mass spectrometry analysis.
Not available
S-EPMC5032999 | biostudies-literature
UnknownImmune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1).
Not available
S-EPMC10112802 | biostudies-literature
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