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ProteomicsIdentification of ALDH6A1 as a Potential Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome
Various liver diseases, including hepatocellular carcinoma (HCC), have been linked to mitochondrial dysfunction, a condition characterized by abnormal levels of nitric oxide (NO) and reactive oxygen species (ROS). In this study, we subjected the human liver mitochondrial proteome to an extensive qua...
ORGANISM(S): Homo sapiens (Human) 
2020-01-29 | PXD014252 | Pride
Aldh6a1 Nitric oxide Hepatocellular carcinoma Reactive oxygen species Mitochondria 
ProteomicsAtlas of lysine propionylation in the human right atrium reveals ALDH6A1-NADH pathway involved in the new-onset atrial fibrillation in aging after coronary artery bypass grafting
Lysine propionylation modification (Kpr) plays an important role in the pathogenesis of several cardiovascular diseases, but the role of Kpr in postoperative atrial fibrillation (POAF) is unclear. Here, we established an atlas of proteomics and propionylation proteomics in the atrial appendage tissu...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD059607 | Pride
Propionylation Aldh6a1 Atrial fibrillation Coronary artery bypass grafting 
UnknownABAT and ALDH6A1, regulated by transcription factor HNF4A, suppress tumorigenic capability in clear cell renal cell carcinoma.
Not available
S-EPMC7038561 | biostudies-literature
UnknownThe downregulated drug-metabolism related ALDH6A1 serves as predictor for prognosis and therapeutic immune response in gastric cancer.
Not available
S-EPMC9512493 | biostudies-literature
UnknownDownregulation of ALDH6A1 is a New Marker of Muscle Insulin Resistance in Type 2 Diabetes Mellitus.
Not available
S-EPMC8887615 | biostudies-literature
TranscriptomicsStudy of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: A translational research study of the Hellenic Cooperative Oncology Group (HeCOG)
Background. Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most amenable to angiogenesis modulation are lacking. Patients and Met...
ORGANISM(S): Homo sapiens 
2013-12-18 | GSE53127 | GEO
TranscriptomicsStudy of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: A translational research study of the Hellenic Cooperative Oncology Group (HeCOG)
Background. Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor subsets most amenable to angiogenesis modulation are lacking. Patients and Me...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-53127 | biostudies-arrayexpress
MetabolomicsLoss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells

Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we fo...

2026-02-06 | MTBLS13473 | MetaboLights
UnknownALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1.
Not available
S-EPMC12932784 | biostudies-literature
ProteomicsLoss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells
Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we found...
ORGANISM(S): Mus Musculus 
2025-12-10 | PXD071798 |
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