Sort   by:  
 Page size 
TranscriptomicsDosage dependent tumor suppression by histone deacetylases 1/2
Dosage dependent tumor suppression by histone deacetylases 1/2
ORGANISM(S): Mus musculus 
2013-03-21 | E-MTAB-1448 | biostudies-arrayexpress
ProteomicsAP-MS analysis of human histone deacetylase interactions in CEM-T cells
Affinity purification-mass spectrometry (AP-MS) datasets of eleven human histone deacetylases (HDACs). Affinity-tagged (GFP) HDACs were expressed in a human CEM-T cell line. For label-free analysis, proteins were digested by trypsin in-solution and peptides separated across a linear 180 min gradient...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-07 | MSV000079563 | MassIVE
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
ProteomicsDissection of acetylomic profiles in T cell lymphoma following histone deacetylases inhibition
The aim was to dissect molecular changes in histone and non-histone protein acetylation dynamics following the genetic or pharmacological inhibition of HDAC activity in a model of Anaplastic Large Cell Lymphoma (ALCL), a T cell non-Hodgkin lymphoma, predominantly found in children and adolescents.
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD030503 | Pride
Acetylomics Histone deacetylase inhibitors Anaplastic large cell lymphoma Histone deacetylases Proteomics 
TranscriptomicsTranscription profiling of Arabidopsis treated with Trichostatin A (TSA) to inhibit of histone deacetylase in Arabiodopsis thaliana
Histone acetylation is involved in the regulation of gene expression in plants and eukaryotes. Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from histones, which is associated with the repression of gene expression. To study the role of histone acetylation in ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-12 | E-GEOD-3783 | biostudies-arrayexpress
TranscriptomicsPolycomb Repressor Complex2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results show that H3K27me3-enriched genes show no de-repression in REST-/- ESCs, while REST target genes show significant de-repression. RNA-seq was ...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-59442 | biostudies-arrayexpress
TranscriptomicsSelective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition
Histone acetylation and other modifications of the chromatin are important regulators of gene expression and, consequently, may contribute to drug-induced behaviors and neuroplasticity. Previous studies have shown that a reduction on histone deacetylase (HDAC) activity results on the enhancement of ...
ORGANISM(S): Mus musculus 
2010-09-17 | E-GEOD-17731 | biostudies-arrayexpress
TranscriptomicsHDAC1/2 and CD4+ T cells
Dynamic changes in histone acetylation patterns are mediated by the activity of histone acetyltransfereases (HATs) and histone deacetylases (HDACs) and are key events in the epigenetic regulation of gene expression. The application of HDAC inhibitors revealed a variety of T cell functions controlled...
ORGANISM(S): Mus musculus 
2014-03-30 | E-MTAB-2184 | biostudies-arrayexpress
GenomicsPolycomb Repressor Complex 2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results showed that a majority of REST-bound genomic regions were not associated with H3K27me3 enrichment and loss of H3K27me3 enrichment was not a g...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-48320 | biostudies-arrayexpress
GenomicsHistone acetylation regulates intracellular pH
Differences in global levels of histone acetylation occur in normal and cancer cells, although the reason cells regulate these levels has remained unclear. Here we demonstrate a role for histone acetylation in regulating intracellular pH (pHi). As pHi decreases, histones are globally deacetylated by...
ORGANISM(S): Homo sapiens 
2012-11-04 | E-GEOD-40114 | biostudies-arrayexpress
Sort   by:  
 Page size