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ProteomicsQuantitative proteomics of Giardia exposures to HKMT inhibitors
We explored differential protein expression (DEPs) during sublethal exposures of HKMT inhibitors (BIX-01294 = 10uM (B), Chaetocin = 20uM (C)) in log-phase (growth; TY) and encystation (differentiation; EC) at 8 and 24 hours relative to DMSO controls (D). In total, 18,527 peptides from 1,981 proteins...
ORGANISM(S): Giardia lamblia ATCC 50803 
2020-08-04 | PXD016747 | Pride
Hkmt inhibitor Bix-01294 Chaetocin Giardia Protein methylation 
TranscriptomicsBreast cancer cell lines treated with EZH2 inhibitor compounds
Loss of H3K27me3 repressive chromatin histone marks, maintained by the histone methyltransferase (HKMT) EZH2, may lead to reversal of epigenetic silencing in tumor cells and have therapeutic potential. Using a cell-based assay, we have identified three compounds from a HKMT inhibitor chemical libra...
ORGANISM(S): Homo sapiens 
2013-08-27 | E-GEOD-36131 | biostudies-arrayexpress
TranscriptomicsBreast cancer cell lines treated with EZH2 inhibitor compounds
Loss of H3K27me3 repressive chromatin histone marks, maintained by the histone methyltransferase (HKMT) EZH2, may lead to reversal of epigenetic silencing in tumor cells and have therapeutic potential. Using a cell-based assay, we have identified three compounds from a HKMT inhibitor chemical librar...
ORGANISM(S): Homo sapiens 
2013-08-27 | GSE36131 | GEO
UnknownDesigning synthetic drugs against Plasmodium falciparum: a computational study of histone-lysine N-methyltransferase (PfHKMT).
Not available
S-EPMC4009081 | biostudies-literature
GenomicsHomo sapiens
Breast cancer cell lines treated with EZH2 inhibitor compounds
PRJNA152943 | ENA
UnknownInhibition of NADPH Oxidase 4 (NOX4) Signaling Attenuates Tuberculous Pleural Fibrosis.
Not available
S-EPMC6351931 | biostudies-literature
UnknownBreast cancer cell lines treated with EZH2 inhibitor compounds
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-36131 | biostudies-other
UnknownInteraction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage.
Not available
S-EPMC5003120 | biostudies-literature
UnknownClass I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
Not available
S-EPMC4556395 | biostudies-literature
TranscriptomicsExpression data from mouse pancreatic cell lines treated with chromatin-targeting small molecules
We measured the genome-wide expression changes induced by 29 compounds targeting HDACs, DNMTs, histone lysine methyltransferases (HKMTs), and protein arginine methyltransferases (PRMTs) in pancreatic M-NM-1- and M-NM-2-cell lines. We used microarrays to detail the global programme of gene-expression...
ORGANISM(S): Mus musculus 
2012-03-09 | E-GEOD-36379 | biostudies-arrayexpress
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