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GenomicsHNF4A-binding sites in HepG2 hepatoblastoma cells treated with TGF-beta
Specific regulation of target genes by transforming growth factor-β (TGF-β) in a given cellular context is determined in part by transcription factors and cofactors that interact with the Smad complex. In the present study, we determined Smad2 and Smad3 (Smad2/3) binding regions in the promoters of ...
ORGANISM(S): Homo sapiens 
2011-06-08 | E-GEOD-28845 | biostudies-arrayexpress
TranscriptomicsHNF4A is required to specify glucocorticoid action in the liver - RNAseq
The glucocorticoid receptor (GR) is a nuclear hormone receptor critical to the regulation of energy metabolism and the inflammatory response. The actions of GR have been shown to be highly dependent on context. Here, we demonstrate the necessity for liver lineage-determining factor hepatocyte nuclea...
ORGANISM(S): Mus musculus 
2021-04-09 | E-MTAB-10247 | biostudies-arrayexpress
TranscriptomicsHigh throughput sequencing of human HepG2 DNA immunoprecipitated with FOXA2, HNF4a and NRF2/GABP
In each cell type the expression of genes is regulated by the action of a large number of transcription factors, but so far we have only a rudimentary knowledge of the location of the gene regulatory elements where they bind. This can now be addressed with genome-wide ChIP experiments. In a previous...
ORGANISM(S): Homo sapiens 
2009-06-09 | E-MTAB-115 | biostudies-arrayexpress
GenomicsTAF4 promotes pre-initiation complex formation and HNF4A occupancy of regulatory elements required to activation post-natal gene expression programme in hepatocytes (ChIP-seq)
The nuclear receptor HNF4A regulates embryonic and post-natal hepatocyte gene expression. Using hepatocyte-specific inactivation in mice, we show that the TAF4 subunit of TFIID acts as a cofactor for HNF4A in vivo and that HNF4A interacts directly with the TAF4-TAF12 heterodimer in vitro. In vivo, T...
ORGANISM(S): Mus musculus 
2014-09-25 | E-GEOD-57807 | biostudies-arrayexpress
TranscriptomicsTAF4 promotes pre-initiation complex formation and HNF4A occupancy of regulatory elements required to activation post-natal gene expression programme in hepatocytes (RNA-seq)
The nuclear receptor HNF4A regulates embryonic and post-natal hepatocyte gene expression. Using hepatocyte-specific inactivation in mice, we show that the TAF4 subunit of TFIID acts as a cofactor for HNF4A in vivo and that HNF4A interacts directly with the TAF4-TAF12 heterodimer in vitro. In vivo, T...
ORGANISM(S): Mus musculus 
2014-09-25 | E-GEOD-57712 | biostudies-arrayexpress
GenomicsGenome-wide DNA-binding profile of HNF4A and genome occupancy of the histone modifications H3K4me1, H3K27ac in kidneys from Bicc1 WT and KO mice by ChIPseq.
Mutations in Bicaudaul C 1 (BICC1), evolutionary conserved RNA-binding protein, cause renal cysts in mice and humans. These renal cysts are reminiscent of Polycystic Kidney Disease (PKD). How BICC1 is involved in the pathogenesis of polycystic kidney disease is still unknown. Recent studies highligh...
ORGANISM(S): Mus musculus 
2020-01-20 | E-MTAB-6424 | biostudies-arrayexpress
GenomicsChIP-seq data of HNF4A, CEBPA, FOXA1, H3K27ac,
We profiled the genome-wide occupancy of three tissue-specific transcription factors, HNF4A, CEBPA and FOXA1, as well as the genome-wide occurrence of the histone mark, H3K4me3 in the livers of two inbred parental mouse strains (C57BL/6J and CAST/EiJ) and their F1 crosses. We also included H3K27ac d...
ORGANISM(S): Mus 
2016-06-30 | E-MTAB-4089 | biostudies-arrayexpress
GenomicsTranscriptomic profiling of Hnf4a liver knockout mice (AlbCre-Hnf4a fl/fl) vs control (Hnf4a fl/fl) mice.
Transcriptomic profiling of Hnf4a liver knockout mice (AlbCre-Hnf4a fl/fl) vs control (Hnf4a fl/fl) mice.
PRJNA796492 | ENA
TranscriptomicsExpression Data from HNF4a RNAi Knockdown in HepG2 cells
HNF4a is an important liver transcription factor that regulates at least a thousand genes in the liver. Here we used expression profiling in HepG2 cells, a hepatocellular carcinoma cell line, in which HNF4a was knocked down by RNAi to identify some of those target genes. This dataset accompanies the...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-29084 | biostudies-arrayexpress
GenomicsRNA-seq mouse HNF4a KO
RNA-seq mouse HNF4a KO
PRJEB6094 | ENA
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