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MetabolomicsLimosilactobacillus fermentum-derived 4-guanidinobutyric acid promotes intestinal urate excretion via the HNF4α-ABCG2 axis to alleviate hyperuricemia

Hyperuricemia is a prevalent metabolic illness and an established risk factor for gout and chronic renal disease. Present urate-lowering medications are often limited by side effects, highlighting the necessity for innovative strategies. The gut microbiota has a role in urate homeostasis; however...

2026-01-26 | MTBLS13637 | MetaboLights
ProteomicsTotal cellular proteome analysis of mutant and WT HNF4alpha Hepatic Progenitor Stage Cells
Post-translational modification of proteins has been shown to control different aspects of protein biology. We have previously implicated a SUMO consensus motif in HNF4alpha’s carboxylic terminus as an important regulator of protein biology during stem cell differentiation. In this study, we have ge...
ORGANISM(S): Homo sapiens (Human) 
2019-06-17 | PXD013737 | Pride
Human Hnf4alpha Embryonic stem cells Hepatic progenitor Sumo 
TranscriptomicsGene expression data from livers of 3-month-old HNF4alpha knockout mice
HNF4alpha is a master regulator of hepatic differentiation. In this study, HNF4alpha was deleted in adult mice using a Cre-LoxP system where Cre recombinase was delivered using an AAV8 virus. Total RNA was isolated from the livers of HNF4alpha-floxed mice (mixed backgournd) treated with either Contr...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-35782 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreatic islets from wild type, pancreas-specific Hnf4alpha knockout, heterozygous Hnf1alpha, and double mutant mice
Gene expression differences between wild-type, pancreas-specific Hnf4alpha knockout (Hnf4a-pKO), heterozygous Hnf1alpha (Tcf1) (Hnf1aHET), and double mutant (Hnf4a-pKO;Hnf1aHET) mouse pancreatic islets were assesed using amplified RNA samples from islets of matched quality and endocrine purity, obta...
ORGANISM(S): Mus musculus 
2010-03-01 | E-MEXP-1729 | biostudies-arrayexpress
GenomicsTargets of transduced Foxa and Hnf4alpha proteins in mouse embryonic fibroblasts (MEFs).
Targets of transduced Foxa and Hnf4alpha proteins in mouse embryonic fibroblasts (MEFs).
PRJNA600509 | ENA
GenomicsTargets of Hnf4alpha during conversion from mouse embryonic fibroblasts (MEFs) to hepatocyte-like (iHep) cells.
Targets of Hnf4alpha during conversion from mouse embryonic fibroblasts (MEFs) to hepatocyte-like (iHep) cells.
PRJNA490545 | ENA
UnknownMapping of HNF4alpha target genes in intestinal epithelial cells.
Not available
S-EPMC2761415 | biostudies-literature
TranscriptomicsGlobal expression analysis of HNF4alpha and HNFgamma-mediated transcriptional control
Hepatocyte nuclear factor-4α (HNF4α, NR2A1) is a nuclear receptor which has a critical role in hepatocyte differentiation and the maintenance of homeostasis in the adult liver. However, a detailed understanding of native HNF4α in the steady state remains to be elucidated. Here we report the native H...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-18973 | biostudies-arrayexpress
TranscriptomicsSex-dependent and HNF4alpha-dependent Mouse Liver Gene Expression
A series of dual-channel gene expression profiles obtained using Rosetta/Agilent Whole Mouse Genome oligonucleotide microarrays, 4 x 44K format, was used to identify sex-dependent and HNF4alpha-dependent differences in gene expression in adult mouse liver. This series is comprised of four sex-genoty...
ORGANISM(S): Mus musculus 
2008-03-21 | GSE10390 | GEO
UnknownDown-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs.
Not available
S-EPMC2667705 | biostudies-literature
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