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Transcriptomicsc-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells [MCF-7:5C]
The emergence of anti-estrogen resistance in breast cancer is an important clinical phenomenon affecting long-term survival in this disease. Identifying factors that convey cell survival in this setting may guide improvements in treatment. Estrogen (E2) can induce apoptosis in breast cancer cells th...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-59535 | biostudies-arrayexpress
TranscriptomicsChanges in Global Gene Expression Associated with 3D Structure of Tumors: an ex vivo Matrix-Free Mesothelioma Spheroid Model
Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involved in multicellular tumor microenvironments, however, are difficult to study ex vivo. Here, we generated a matrix-free tumor spheroid model using the NCI-H226 mesothelioma cell line and compared the gene expre...
ORGANISM(S): Homo sapiens 
2012-06-20 | E-GEOD-37629 | biostudies-arrayexpress
TranscriptomicsExpression analysis of CaMsrB2-transformed rice (Oryza sativa L. cv. ILMI) without/with Bar selection marker under drought stress conditions
Methionine sulfoxide reductases catalyze the reduction of MetSO back to the correct Met residue. Previously, the gene of Capsicum annuum methionine sulfoxide reductase B2 was isolated and CaMSRB2-overexpressing tomato shows enhanced growth, which may trigger increased resistance to the pathogens. To...
ORGANISM(S): Oryza sativa 
2013-04-01 | E-GEOD-41204 | biostudies-arrayexpress
GenomicsArid3a modulates the first cell fate decision by direct regulation of both embryonic and extraembryonic gene expression (ChIP-Seq)
Arid3a, a transcription factor known for its requirement in B-lymphocyte development, has been recently identified as a member of ES cell pluripotency network. Arid3a is moderately expressed in ES cells, and its expression is gradually increased during differentiation. Since Arid3a shows the highest...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-56876 | biostudies-arrayexpress
TranscriptomicsRNAseq of Human Umbilical Vein Endothelial Cells treated with Insulin in the presence or absence of TGF-beta kinase inhibitor SB431542 for 90 minute.
Endothelial cells play many important role during development and development of diseases. Endothelial dysfunction which is commonly seen in diabetes patients is thought to be one of the first step that leads to adverse events such as retinopathy, nephropathy, and atherosclerosis. To examine to whic...
ORGANISM(S): Homo sapiens 
2019-01-15 | E-MTAB-6841 | biostudies-arrayexpress
UnknownLife extension factor klotho enhances cognition.
Not available
S-EPMC4176932 | biostudies-literature
GenomicsAnalyses of the chromatin and transcriptional basis for lateral inhibition in isolated intestinal epithelial cells.
We analyzed chromatin modifications, DNaseI-hypersensitive sites, and occupancy of a key secretory-lineage transcription factor, ATOH1. We found that lateral inhibition in the intestine occurs through ATOH1 exerting direct control within a broadly permissive chromatin state that is established in st...
ORGANISM(S): Mus musculus 
2014-01-06 | E-GEOD-51458 | biostudies-arrayexpress
TranscriptomicsRNA-Seq and RNA Polymerase II ChIP-Seq of mouse spermatogenesis
To characterize gene expression in spermatogenesis we sequenced eight mRNA samples from testes of juvenile mice aged between 6 and 38 days post partum. We then classified gene expression profiles and found over 1,000 meiotically-expressed protein-coding genes that have not been previously reported i...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-44346 | biostudies-arrayexpress
UnknownUbiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
Not available
S-EPMC3032702 | biostudies-literature
TranscriptomicsTranscriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells
To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β). After 7 days transcriptomic profiling by bulk RNA-seq was performed.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12199 | biostudies-arrayexpress
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