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ProteomicsRibonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules
Circular RNAs (circRNAs) accumulate with age, but their functional impact on aging remains elusive. In this study, we reveal a mechanism by which ribonuclease κ (RNASEK) prevents age-dependent circRNA accumulation by promoting its degradation. Through a genetic screen targeting ribonucleases, we ide...
ORGANISM(S): Caenorhabditis Elegans 
2026-01-15 | PXD073097 |
TranscriptomicsFunctional phenotypes alteration on dendritic cells between tolerance and immnunity
Dendritic cells (DC) are key regulators of immunological responses, immunity and tolerance. Due to their differentiation capacities, they have emerged as a promising tool for therapeutic applications. However, there are poorly understood functional DC-specific markers and cellular mechanisms for in-...
ORGANISM(S): Mus musculus 
2014-07-26 | E-GEOD-59754 | biostudies-arrayexpress
TranscriptomicsExpression of M-CSF from cryopreserved teeth-derived human periodontal ligament cells with different freezing protocols
This study investigated which genes regarding root resorption are upregulated by cryopreservation and whether cryopreservation affects the expression of Macrophage M-bM-^@M-^Scolony stimulating factor. We manufactured the customized template which was made of genes selected regarding root resorption...
ORGANISM(S): Homo sapiens 
2013-01-19 | E-GEOD-43611 | biostudies-arrayexpress
TranscriptomicsIntermittent fasting promotes remodeling of neural and vascular networks in visceral white adipose tissue
Intermittent fasting (IF) improves metabolic health, in part by remodeling white adipose tissue (WAT), yet the underlying mechanisms remain elusive. Here, we show that IF induces coordinated neurovascular remodeling in visceral WAT, marked by increased angiogenesis and sympathetic innervation. Using...
ORGANISM(S): Mus musculus 
2026-07-13 | E-MTAB-16066 | biostudies-arrayexpress
TranscriptomicsMethylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy (methylation)
Alterations in DNA methylation and gene expression have been implicated in the development of human dilated cardiomyopathy (DCM). In this study, we analyzed DNA methylomes (Infinium 450K HumanMethylation BeadChip) and characterize differentially methylated probes between the left and right ventricle...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-81337 | biostudies-arrayexpress
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