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TranscriptomicsEpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
Background: The Epithelial Cell Adhesion Molecule (EpCAM) has been shown to be strongly expressed in human breast cancer and cancer stem cells and its overexpression has been supposed to support tumor progression and metastasis. However, effects of EpCAM overexpression on normal breast epithelial ce...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-37172 | biostudies-arrayexpress
TranscriptomicsEpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth.
Introduction: The Epithelial Cell Adhesion Molecule (EpCAM) has been shown to be strongly expressed in human breast cancer and cancer stem cells and its overexpression has been supposed to support tumor progression and metastasis. However, effects of EpCAM overexpression on normal breast epithelial ...
ORGANISM(S): Homo sapiens 
2013-06-13 | E-GEOD-39071 | biostudies-arrayexpress
ProteomicsUrinary proteomics in youths with and without type 1 diabetes
Diabetic kidney disease is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete. In this study, we aimed to uncover the early, dysregulated pathways in the diabetic kidney before the onset of microalbuminur...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD017213 | Pride
Proteomics Urine Type 1 diabetes 
UnknownIdentification of metastasis-suppressive microRNAs in primary melanoma.
Not available
S-EPMC4565532 | biostudies-literature
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in resting human skeletal muscle of sedentary and highly-trained individuals.
We used gene microarray analysis to compare the global expression profile of genes involved in adaptation to exercise training in skeletal muscle from chronically strength/resistance trained (ST), endurance trained (ET) and untrained control subjects (Con). Resting skeletal muscle samples (~100mg) ...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-9405 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of genes affected by the loss of Brd4 in the embryonic stem cells
BRD4 is an important epigenetic reader implicated in the pathogenesis of a number of different cancers and other diseases. Brd4-null mouse embryos die shortly after implantation and are compromised in their ability to maintain the inner cell mass (ICM), which gives rise to embryonic stem cells (ESC...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-59142 | biostudies-arrayexpress
ProteomicsUrinary peptidomics in youths with and without type 1 diabetes
Although the early mechanisms responsible for diabetic kidney disease remain unclear, it is widely believed that chronic hyperglycemia disrupts the proteolytic milieu in the diabetic kidney and may contribute to early kidney injury. We thus performed mechanistic peptidomics in type 1 diabetes before...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD012210 | Pride
Human Peptidomics Urine Type 1 diabetes Lc-ms/ms 
TranscriptomicsMicroarray Transcriptome Comparison Subzero Temperature and Optimal Temperature Growth in Psychrobacter arcticus 273-4
Permafrost soils are extreme environments that exert low-temperature, desiccation and starvation stress on bacteria over thousands to millions of years. To understand how Psychrobacter arcticus 273-4 survived for > 20,000 years in permafrost, transcriptome analysis was performed during growth at 22...
ORGANISM(S): Psychrobacter arcticus 273-4 
2010-05-15 | E-GEOD-12871 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of normal and pathological synovial fibroblasts
The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from ...
ORGANISM(S): Homo sapiens 
2011-10-24 | E-GEOD-29746 | biostudies-arrayexpress
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