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TranscriptomicsTranscription profiling of mouse mammary tumours developed in Wap-Cre;Etv6-NTRK3 mice
We report a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Whey acidic protein (Wap) promoter-driven Cre lead...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9355 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mammary tissues from mouse model of breast cancer conditionally expressing Etv6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation
For the largest class of human tumors, those of epithelial origin, little is known about their initiating genetic hits or cells of origin. Whether tissue stem cells or more committed progenitors are targets for transformation is also uncertain. Experience in hematopoietic malignancies and sarcomas ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9343 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model for ETV6-NTRK3 (EN) fusion oncoprotein expresson
We report a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Whey acidic protein (Wap) promoter-driven Cre lead...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9353 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model that recapitulates the ETV6-NTRK3 fusion oncoprotein the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma
We report a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Whey acidic protein (Wap) promoter-driven Cre lead...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9354 | biostudies-arrayexpress
TranscriptomicsEssential roles for chromatin protein L3mbtl2 in pluripotent stem cells
In order to determine the impact of L3mbtl2 on genome wide mRNA expression microarray analysis was carried out in L3mbtl2 knock out ES cells and wild type ES cells. The same analysis was also carried out in knock out cells infected with L3mbtl2-F vector and a control vector. Experiment to study targ...
ORGANISM(S): Mus musculus 
2012-07-02 | E-GEOD-38801 | biostudies-arrayexpress
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