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TranscriptomicsHuman lupus netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules
Our group has proposed that low-density granulocytes (LDGs) play an important role in lupus pathogenesis, as they can damage endothelial cells and synthesize increased levels of proinflammatory cytokines and type I interferons. LDGs have a heightened capacity to synthesize neutrophil extracellular t...
ORGANISM(S): Homo sapiens 
2011-06-22 | E-GEOD-26975 | biostudies-arrayexpress
TranscriptomicsCross-species transcriptional networks in Diabetic Glomerulopathy in mouse and man
Murine models have been valuable instruments in defining the pathogenesis of diabetic nephropathy (DN), but they only partially recapitulate disease manifestations of human DN, limiting their utility . In order to define the molecular similarities and differences between human and murine DN, we perf...
ORGANISM(S): Mus musculus 
2012-12-10 | E-GEOD-33744 | biostudies-arrayexpress
UnknownResponsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.
Not available
S-EPMC8072405 | biostudies-literature
ProteomicsSirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease
Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from hyperfiltration. We hypothesized that changes in metabolism in DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that...
ORGANISM(S): Mus Musculus 
PXD037819 | panorama
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