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ProteomicsGDF15 Resolves Liver Inflammation in MASH Independently of Reductions in Food Intake or Weight Loss
Growth differentiation factor 15 (GDF15) is strongly associated with metabolic dysfunction-associated steatohepatitis (MASH), yet whether it drives disease or protects against liver injury remains unresolved. Using thermoneutral mouse models that closely mimic human MASH, we show that loss of GDF15 ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD083028 | Pride
Mouse Proteomics Dia Plasma 
ProteomicsLCMS-based plasma proteome analysis of heart failure patients with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF) for biomarker identification and patient profiling
Heart failure (HF) diagnosis is complicated by varied pathophysiology, nonspecific symptoms and underlying comorbidities. This patient heterogeneity makes accurate treatment challenging and, as a result, can lead to worse clinical outcomes and increased healthcare cost. Measuring the plasma concentr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-25 | PXD050447 | Pride
Hfpef  hfref Heart failure  lc-ms  proteomics  plasma  biomarker 
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