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MetabolomicsGut Microbiota-Proline Axis Drives HFpEF Through Fibroblast Ferroptosis

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiometabolic disorder closely associated with systemic metabolic dysregulation. In this study, plasma samples were collected from C57BL/6J mice subjected to a high-fat diet–induced HFpEF model, with or without intervention, an...

2026-01-16 | MTBLS13700 | MetaboLights
MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
ProteomicsHuman HFpEF Myocardial Proteomics
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD045677 | Pride
Proteomics Myocardium Obesity Molecular medicine Heart disease Human 
ProteomicsProteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)
Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, evidence-based therapies for HFpEF are rare, likely due to an incomplete understanding of this disease. This study sought to identify the cardiac-specific features of protein and phosphoprotein in a muri...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033501 | Pride
Metabolism Proteomics Sirt3 Mitochondria Hfpef Titin Phosphoproteomics 
ProteomicsAcetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment
Aims: Despite the high prevalence of heart failure with preserved ejection fraction (HFpEF), the pathomechanisms remain elusive and specific therapy is lacking. Disease-causing factors include metabolic risk, notably obesity. However, proteomic changes in HFpEF are poorly understood, hampering thera...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-12 | PXD036259 | Pride
Diastolic dysfunction  proteomics  obesity  meta-inflammation  stiffness 
GenomicsHFpEF ventricular biopsies
DEG and microRNA signatures from HFpEF ventricular biopsies.
PRJEB62450 | ENA
ProteomicsSemaglutide exerts stronger cardioprotective effects than caloric restriction in mice with HFpEF
Patients with heart failure with preserved ejection fraction (HFpEF) often have an unfavorable cardiometabolic profile, and obesity-related HFpEF has become a well-recognized HFpEF sub-phenotype. Targeting this unfavorable cardiometabolic profile may therefore represent a rational treatment strategy...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD034625 | Pride
Hfpef Plasma Heart Proteomics Cardioprotection Semaglutide 
ProteomicsMyeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation
This project characterizes chamber-specific proteomic remodeling in a murine three-hit HFpEF model that develops right ventricular dysfunction, using chow, hypoxia alone, and HFD+L-NAME as control conditions. The three-hit model (hypoxia, high-fat diet, and L-NAME) recapitulates key features of huma...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD074772 | Pride
Heart Mouse Hfpef Hypoxia 
ProteomicsExperiment of proteomics and S-nitrosylation modifications proteomics in the hearts of HFpEF mice
We established a mouse model of HFpEF using 8-12-week-old male C57BL/6J mice, and conducted proteomic and nitrosylation modification profiling on the hearts of the control group (n=5) and the HFpEF mice (n=5) to determine the phenotypic changes.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD075362 | Pride
Hfpef Heart S-nitrosylation Mouse Post-translational modification Proteomics Lc-ms/ms 
ProteomicsMyocardial Proteome in Human Heart Failure with Preserved Ejection Fraction
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2025-04-11 | PXD060431 | Pride
Oxidative phosphorylation Metabolism Fatty acids Proteomics Obesity Myocardium Molecular medicine : heart failure 
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