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MetabolomicsSemaglutide targets muscle mitochondria to regulate osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14059 | MetaboLights
MetabolomicsSemaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritis

Metabolic and inflammatory diseases often coexist, and become important challenges facing global health, and obesity has shown to be a susceptibility factor for osteoarthritis (OA). As a metabolic regulatory drug for lowering blood sugar and body weight, semaglutide has shown additional therapeut...

2026-05-06 | MTBLS14295 | MetaboLights
ProteomicsSemaglutide targets mitochondria to regulate metabolism and inflammation in sarcopenia and osteoarthritis
Metabolic and inflammatory diseases often coexist, and become important challenges facing global health. As a traditional anti-obesity drug, semaglutide is reported to have therapeutic effects in sarcopenia and osteoarthritis (OA), but its mechanism of action still needs to be explored. Here we empl...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-06 | PXD073074 | Pride
C2c12 Semaglutide Mitochondria 
TranscriptomicsSemaglutide Attenuates Neuroinflammation in Mice
Bulk RNA sequencing of the hippocampus from mice treated with semaglutide or vehicle control prior to lipopolysaccharide (LPS)-induced neuroinflammation.
ORGANISM(S): Mus musculus 
2026-07-01 | E-MTAB-17123 | biostudies-arrayexpress
TranscriptomicsSemaglutide Attenuates Neuroinflammation in Mice
Single-nucleus RNA sequencing (snRNA-seq) of the hippocampus and dorsal vagal complex (DVC) from mice treated with semaglutide or vehicle control prior to lipopolysaccharide (LPS)-induced neuroinflammation.
ORGANISM(S): Mus musculus 
2026-05-20 | E-MTAB-16829 | biostudies-arrayexpress
ProteomicsSemaglutide exerts stronger cardioprotective effects than caloric restriction in mice with HFpEF
Patients with heart failure with preserved ejection fraction (HFpEF) often have an unfavorable cardiometabolic profile, and obesity-related HFpEF has become a well-recognized HFpEF sub-phenotype. Targeting this unfavorable cardiometabolic profile may therefore represent a rational treatment strategy...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD034625 | Pride
Hfpef Plasma Heart Proteomics Cardioprotection Semaglutide 
GenomicsSemaglutide Attenuates Neuroinflammation in Mice
Semaglutide Attenuates Neuroinflammation in Mice
PRJEB113706 | ENA
GenomicsEffect of semaglutide treatment in aged mice
Effect of semaglutide treatment in aged mice
PRJNA1492491 | ENA
GenomicsSemaglutide Attenuates Neuroinflammation in Mice
Semaglutide Attenuates Neuroinflammation in Mice
PRJEB110918 | ENA
ProteomicsProteomics characterizing the mechanisms of semaglutide in diabetes mice with cognitive impairment
This study aims to investigate the neuroprotective effects of semaglutide in Diabetes-associated cognitive decline (DACD), while also exploring the underlying mechanisms targeting anti-oxidative effects.Methods: This study evaluated the antioxidant properties of semaglutide in a DACD model. To inves...
ORGANISM(S): Mus Musculus 
2024-10-21 | PXD056999 |
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