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TranscriptomicsMechanisms of CS-related A/J lung tumorigenesis
The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening system in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops tumors spontaneously. Moreover, there is a considerable...
ORGANISM(S): Mus musculus 
2014-08-29 | E-MTAB-1871 | biostudies-arrayexpress
TranscriptomicsMechanisms of CS-related A/J lung tumorigenesis
The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening system in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops tumors spontaneously. Moreover, there is a considerable...
ORGANISM(S): Mus musculus 
2014-08-29 | E-MTAB-1872 | biostudies-arrayexpress
ProteomicsRespiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice [RNE data]
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-13 | PXD016466 | Pride
Lc-msms Respiratory nasal epithelium Mouse Systems toxicology Itraq 
ProteomicsRespiratory effects of exposure to aerosol from the candidate modified-risk tobacco product THS 2.2 in an 18-month systems toxicology study with A/J mice [Lung data]
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-13 | PXD016460 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsImpact of whole-body versus nose-only exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model [Lung data]
The objective of this study was to compare the biological and toxicological response of apolipoprotein E-deficient (Apoe-/-) mice to 3R4F mainstream smoke exposure for 2 months in whole-body exposure chambers (WBEC) and nose-only exposure chambers (NOEC). Female ApoE-/- mice were randomized into fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-26 | PXD018185 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
TranscriptomicsP12365 - A/J COPD - Parenchyma
Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disorder that is the result of extended exposure of the airways to noxious stimuli, principally cigarette smoke (CS). The mechanisms through which COPD evolves are not fully understood though it is believed that the disease process includ...
ORGANISM(S): Mus musculus 
2014-05-14 | E-MTAB-1426 | biostudies-arrayexpress
ProteomicsA 7-month e-vapor aerosol inhalation toxicology study in C57BL/6 mice [Lung data]
A 7-month inhalation study in C57BL/6 mice was conducted to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation or switching to an e-vapor product after 3 months of exposure to 3R4F cigarette smoke (CS). In this study,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-31 | PXD019918 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsAlterations in the sputum proteome and transcriptome in smokers and early-stage COPD patients
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent lung diseases, and involves persistent airflow limitation and incorporates both emphysema and chronic bronchitis. Cigarette smoking has been identified as the main risk factor for disease development and progression. In a basi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080275 | MassIVE
ProteomicsAlterations in the sputum proteome and transcriptome in smokers and early-stage COPD patients
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent lung diseases, and involves persistent airflow limitation and incorporates both emphysema and chronic bronchitis. Cigarette smoking has been identified as the main risk factor for disease development and progression. In a basi...
ORGANISM(S): Homo sapiens (Human) 
2015-08-28 | PXD001977 | Pride
Tmt  copd  sputum  clinical study 
ProteomicsUse of Apoe−/− Mice in an 8-Month Systems Toxicology Inhalation/Cessation Study to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared with Conventional Cigarettes
Cigarette smoking is a major risk factor for the development and progression of cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD), so modified risk tobacco products (MRTPs) are being developed to reduce smoking-related health risks. The present study investigated the hall...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-30 | PXD002530 | Pride
Mouse Lung Cigarette smoke Modified risk tobacco product 
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