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ProteomicsA dual inhibitor of Staphylococcus aureus virulence and biofilm attenuates expression of major toxins and adhesins
Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a phenotypic screen of 35 molecules that were structurally inspired by previous hydroxyamide-based S. aureus virulence inhibitors compiled from commerci...
ORGANISM(S): Staphylococcus aureus 
2018-03-05 | PXD008067 | Pride
Virulence Proteomics Biofilm Target identification Phenotype 
ProteomicsAcyldepsipeptide probes facilitate specific detection of caseinolytic protease P independent of its oligomeric and activity state
Caseinolytic protease P (ClpP) is a tetradecameric peptidase which assembles with chaperones such as ClpX to gain proteolytic activity. Acyldepsipeptides (ADEPs) represent small molecule mimics of ClpX, which bind into hydrophobic pockets on the apical site of the complex and thereby induce activati...
ORGANISM(S): Staphylococcus aureus 
2020-05-26 | PXD015244 | Pride
Thermo fischer q exactive orbitrap Photoaffinity labeling S. aureus 
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