Sort   by:  
 Page size 
TranscriptomicsComparative profiling in 13 muscle disease groups
Summary: Genetic disorders of muscle cause muscular dystrophy, and are some of the most common inborn errors of metabolism. Muscle also rapidly remodels in response to training and innervation. Muscle weakness and wasting is important in such conditions as aging, critical care medicine, space flig...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-GEOD-3307 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
The transcription factor MyoD can coax na?e fibroblasts or otherwise committed cells to adopt the skeletal muscle phenotype by activating the muscle gene expression program. Activation of muscle gene expression occurs in quantal steps with not all the target genes of MyoD being activated at the same...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6487 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of human skeletal muscle samples from metabolic syndrome patients following defined exercise (STRRIDE study)
STRRIDE is an exercise intervention study of different doses and intensities in overweight women and men with the metabolic syndrome. We profiled biopsies from 3 female and 3 male STRRIDE subjects in the “high” exercise group (2,200 kCal/wk). Muscle biopsies were profiled at entry (0h), and afte...
ORGANISM(S): Homo sapiens 
2007-08-02 | E-GEOD-1295 | biostudies-arrayexpress
TranscriptomicsResponse of multiple genes to a chronic dose of corticosteroids in rat muscles
Synthetic glucocorticoids are used therapeutically for a variety of conditions. Both the efficacy and toxicity of corticosteroids arise from their pharmacologically exaggerated effects on target and non-target tissues. For example, beneficial effects deriving from inhibition of the immune system are...
ORGANISM(S): Rattus norvegicus 
2006-06-19 | E-GEOD-5101 | biostudies-arrayexpress
TranscriptomicsExpression data from human liver cell line induced by PCB153
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of differnet diseases is not fully understood. The knowledge of global gene expression will help us to devlop early diagnostic biomarkers for PCB induced h...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-6494 | biostudies-arrayexpress
TranscriptomicsExpression data from human liver cell line induced by PCB77
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of different diseases is not fully understood. The knowledge of global gene expression will help us to develop early diagnostic biomarkers for PCB induced ...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-6869 | biostudies-arrayexpress
TranscriptomicsGene expression and muscle fiber function in a porcine ICU model
Background: Skeletal muscle wasting and impaired muscle function in response to mechanical ventilation and immobilization in intensive care unit (ICU) patients are clinically challenging partly due to (i) the poorly understood intricate cellular and molecular networks; and (ii) the unavailability of...
ORGANISM(S): Sus scrofa 
2009-08-31 | E-GEOD-16348 | biostudies-arrayexpress
TranscriptomicsExpression data from human PBMC induced by mixed Congeners of PCBs at Human equivalence
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of different diseases and disorders are not fully understood. The knowledge of global gene expression will help us to develop early disease or disorder bio...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-22668 | biostudies-arrayexpress
TranscriptomicsSkeletal muscle gene expression in response to resistance exercise: sex specific regulation
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exercise. We u...
ORGANISM(S): Homo sapiens 
2010-12-06 | E-GEOD-24235 | biostudies-arrayexpress
TranscriptomicsSex and aging effect on skeletal muscle transcriptome in humans
The aim of this investigation was to develop a global view of muscle transcriptional differences between older men and women and with aging for each sex. Muscle biopsies were obtained from the biceps brachii of young (age 19~28yrs) and older (age 65~76 yrs) men (7 young, 4 older) and women (7 young,...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-38718 | biostudies-arrayexpress
Sort   by:  
 Page size